Please use this identifier to cite or link to this item:
|Title:||Novel neuroprotective effects with O-benzyl derivative of pralidoxime in soman-intoxicated rodents||Authors:||Loke, W.-K.
|Issue Date:||3-Oct-2005||Citation:||Loke, W.-K., Sim, M.-K., Go, M.-L. (2005-10-03). Novel neuroprotective effects with O-benzyl derivative of pralidoxime in soman-intoxicated rodents. European Journal of Pharmacology 521 (1-3) : 59-69. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ejphar.2005.07.033||Abstract:||Pharmacological properties of oxime reactivators, not related to its ability to regenerate or reactivate nerve agent-inhibited acetylcholinesterase located at nerve synapses, have been reported to be important in protecting against poisoning by the nerve agent soman. Such non-reactivation effects have thus far been associated only with bispyridinium oximes. This study investigated the possibility of creating similar non-reactivation therapeutic effects in the mono-pyridinium ring oxime, pralidoxime (2-PAM) through attachment of alkyl groups of increasing chain length to the oxime functional group. Of the 4 derivatives investigated, only the O-benzyl derivative displayed strong sedative effects in mice and mitigated the development of motor convulsions following soman challenge (1.8 × LD50, subcutaneous). Anticonvulsant effects of this compound were enhanced by co-administration of a non-anticonvulsant dose of atropine sulfate. Administration of equivalent amount of other O-derivatives of pralidoxime failed to elicit similar anticonvulsant actions. Electroencephalographic (EEG) and histopathological studies using the rat model, intoxicated with a lethal dose (1.6 × LD50, s.c.) of soman, confirmed O-benzyl derivative neuroprotective capabilities when used as a pretreatment drug. Microdialysis studies revealed that its neuroprotective effect is related to its ability to attenuate soman-induced increase in acetylcholine. © 2005 Elsevier B.V. All rights reserved.||Source Title:||European Journal of Pharmacology||URI:||http://scholarbank.nus.edu.sg/handle/10635/106176||ISSN:||00142999||DOI:||10.1016/j.ejphar.2005.07.033|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Dec 7, 2019
WEB OF SCIENCETM
checked on Nov 28, 2019
checked on Nov 30, 2019
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.