Please use this identifier to cite or link to this item: https://doi.org/10.1021/mp400359w
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dc.titleMicroneedle integrated transdermal patch for fast onset and sustained delivery of lidocaine
dc.contributor.authorKochhar, J.S.
dc.contributor.authorLim, W.X.S.
dc.contributor.authorZou, S.
dc.contributor.authorFoo, W.Y.
dc.contributor.authorPan, J.
dc.contributor.authorKang, L.
dc.date.accessioned2014-10-29T01:55:43Z
dc.date.available2014-10-29T01:55:43Z
dc.date.issued2013-11-04
dc.identifier.citationKochhar, J.S., Lim, W.X.S., Zou, S., Foo, W.Y., Pan, J., Kang, L. (2013-11-04). Microneedle integrated transdermal patch for fast onset and sustained delivery of lidocaine. Molecular Pharmaceutics 10 (11) : 4272-4280. ScholarBank@NUS Repository. https://doi.org/10.1021/mp400359w
dc.identifier.issn15438384
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106147
dc.description.abstractLidocaine as an analgesic is of particular interest in both acute and chronic pain conditions and is used via injections or transdermal patches. While injections are associated with problems such as patient incompliance, topical administration of lidocaine using patches is less efficient due to variability of drug absorption among individuals, slower drug permeation through the skin, and hence a resultant undesirable delay in analgesic effects. To address this clinical problem, we developed a microneedle integrated transdermal patch (MITP), using a photolithography based process, in which microneedles create micrometer-sized channels in the skin to deliver lidocaine rapidly, while the reservoir patch holding the bulk of the drug enables higher drug loading and carries on to release the drug for prolonged periods. We demonstrated a new approach of drug delivery using microneedles, where drugs diffuse out of microneedles through the porous channels left by dissolving drug particles. MITP was shown to be able to encapsulate up to 70 mg of lidocaine. In vitro permeation through rat skin demonstrated that MITP delivered a significantly higher amount of lidocaine than a commercial patch and with a faster onset of drug permeation. © 2013 American Chemical Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1021/mp400359w
dc.sourceScopus
dc.subjectacute pain
dc.subjectlidocaine
dc.subjectmicroneedles
dc.subjectperipheral neuropathic pain
dc.subjecttransdermal drug delivery
dc.subjecttransdermal patch
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1021/mp400359w
dc.description.sourcetitleMolecular Pharmaceutics
dc.description.volume10
dc.description.issue11
dc.description.page4272-4280
dc.description.codenMPOHB
dc.identifier.isiut000326669400032
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