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https://scholarbank.nus.edu.sg/handle/10635/106122
| Title: | Matrix swelling: A simple model describing extent of swelling of HPMC matrices | Authors: | Sai Cheong Wan, L. Wan Sia Heng, P. Fun Wong, L. |
Keywords: | Case I diffusion Case II model Case II relaxation Coupled Case I Hydroxypropylmethylcellulose Swelling Viscosity |
Issue Date: | 28-Mar-1995 | Citation: | Sai Cheong Wan, L.,Wan Sia Heng, P.,Fun Wong, L. (1995-03-28). Matrix swelling: A simple model describing extent of swelling of HPMC matrices. International Journal of Pharmaceutics 116 (2) : 159-168. ScholarBank@NUS Repository. | Abstract: | The swelling of HPMC matrices was measured by determining the vertical displacement with time using a dial indicator. Curve fitting of the data of swelling was carried out by using the coupled Case I-Case II model. The thickness of the swollen layer formed around the matrix core was greater in HPMC compacts of higher viscosity grade. The rates of Case I (αs coefficient) and Case II (βs coefficient) swelling mechanisms increased with concentration and/or viscosity grade of HPMC. © 1995. | Source Title: | International Journal of Pharmaceutics | URI: | http://scholarbank.nus.edu.sg/handle/10635/106122 | ISSN: | 03785173 |
| Appears in Collections: | Staff Publications |
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