Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.ijpharm.2009.04.042
Title: Layered growth with bottom-spray granulation for spray deposition of drug
Authors: Er, D.Z.L.
Liew, C.V. 
Heng, P.W.S. 
Keywords: Bottom-spray granulation
Circulation pattern
Drug distribution
Fluidized bed
Layered growth
Wurster process
Issue Date: 30-Jul-2009
Citation: Er, D.Z.L., Liew, C.V., Heng, P.W.S. (2009-07-30). Layered growth with bottom-spray granulation for spray deposition of drug. International Journal of Pharmaceutics 377 (1-2) : 16-24. ScholarBank@NUS Repository. https://doi.org/10.1016/j.ijpharm.2009.04.042
Abstract: The gap in scientific knowledge on bottom-spray fluidized bed granulation has emphasized the need for more studies in this area. This paper comparatively studied the applicability of a modified bottom-spray process and the conventional top-spray process for the spray deposition of a micronized drug during granulation. The differences in circulation pattern, mode of growth and resultant granule properties between the two processes were highlighted. The more ordered and consistent circulation pattern of particles in a bottom-spray fluidized bed was observed to give rise to layered granule growth. This resulted in better drug content uniformity among the granule batches and within a granule batch. The processes' sensitivities to wetting and feed material characteristics were also compared and found to differ markedly. Less robustness to differing process conditions was observed for the top-spray process. The resultant bottom-spray granules formed were observed to be less porous, more spherical and had good flow properties. The bottom-spray technique can thus be potentially applied for the spray deposition of drug during granulation and was observed to be a good alternative to the conventional technique for preparing granules. © 2009 Elsevier B.V. All rights reserved.
Source Title: International Journal of Pharmaceutics
URI: http://scholarbank.nus.edu.sg/handle/10635/106107
ISSN: 03785173
DOI: 10.1016/j.ijpharm.2009.04.042
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