Please use this identifier to cite or link to this item: https://doi.org/10.1093/ndt/gfm468
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dc.titleIs a standard fixed dose of mycophenolate mofetil ideal for all patients?
dc.contributor.authorYau, W.-P.
dc.contributor.authorVathsala, A.
dc.contributor.authorLou, H.-X.
dc.contributor.authorChan, E.
dc.date.accessioned2014-10-29T01:54:51Z
dc.date.available2014-10-29T01:54:51Z
dc.date.issued2007-12
dc.identifier.citationYau, W.-P., Vathsala, A., Lou, H.-X., Chan, E. (2007-12). Is a standard fixed dose of mycophenolate mofetil ideal for all patients?. Nephrology Dialysis Transplantation 22 (12) : 3638-3645. ScholarBank@NUS Repository. https://doi.org/10.1093/ndt/gfm468
dc.identifier.issn09310509
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106092
dc.description.abstractBackground. A standard fixed dose of 2 g/day of mycophenolate mofetil (MMF), irrespective of total body weight (TBW), is recommended when used in combination with cyclosporine and corticosteroids in renal transplantation. Methods. To determine the optimal MMF dose in a population with wide variation in TBW, steady-state pharmacokinetics of mycophenolic acid (MPA) was performed in 53 Asian (Chinese, Malay, Indian, Eurasian) renal transplant recipients (RTX) receiving MMF [250-1000 mg twice daily (BD)] for at least 3 months. Blood samples were collected at 0, 0.5, 1, 1.5, 2 and 6 h after the MMF dose and total MPA quantified using HPLC. Results. Drug exposure, as evaluated by AUC ss, 0-12, demonstrated a significant positive correlation with TBW-adjusted MMF dose (outliers omitted: r2 = 0.49, P < 0.0005). An AUCss, 0-12 of 45 mg h/l could be attained with an MMF dose of 12 mg/kg BD. Conclusion. This study proposes that MMF should be dosed based on TBW rather than a fixed dose regimen in RTX. © The Author [2007]. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved.
dc.sourceScopus
dc.subjectAsian
dc.subjectCyclosporine
dc.subjectMycophenolic acid
dc.subjectPharmacokinetics
dc.subjectRenal transplant
dc.subjectWeight-adjusted dosing
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1093/ndt/gfm468
dc.description.sourcetitleNephrology Dialysis Transplantation
dc.description.volume22
dc.description.issue12
dc.description.page3638-3645
dc.description.codenNDTRE
dc.identifier.isiut000251336400039
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