Please use this identifier to cite or link to this item: https://doi.org/10.1007/s11095-008-9681-5
Title: Investigation of the drug-drug interaction between α-lipoic acid and valproate via mitochondrial β-oxidation
Authors: Phua, L.C.
New, L.S. 
Goh, C.W.
Neo, A.H.
Browne, E.R.
Chan, E.C.Y. 
Keywords: β-oxidation
Drug-drug interaction
Lipoic acid
Mitochondrial
Valproate
Issue Date: Nov-2008
Citation: Phua, L.C., New, L.S., Goh, C.W., Neo, A.H., Browne, E.R., Chan, E.C.Y. (2008-11). Investigation of the drug-drug interaction between α-lipoic acid and valproate via mitochondrial β-oxidation. Pharmaceutical Research 25 (11) : 2639-2649. ScholarBank@NUS Repository. https://doi.org/10.1007/s11095-008-9681-5
Abstract: Purpose. To investigate the potential drug-drug interaction (DDI) between lipoic acid (LA) and valproate (VA) via the mitochondrial β-oxidation pathway in rats. Methods. In vitro mitochondrial assays were performed to compare the biotransformation of VA to valproyl-CoA (VA-CoA), in the absence and presence of LA. In vitro microsomal and protein binding assays were performed to elucidate their potential DDI at the microsomal metabolism and distribution levels. A pharmacokinetic study was conducted in Lister Hooded rats to ascertain the in vivo DDI between LA and VA. Results. LA was shown to decrease significantly (p
Source Title: Pharmaceutical Research
URI: http://scholarbank.nus.edu.sg/handle/10635/106084
ISSN: 07248741
DOI: 10.1007/s11095-008-9681-5
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