Please use this identifier to cite or link to this item: https://doi.org/10.1007/s10973-005-7050-8
Title: Interactions between a skin penetration enhancer and the main components of human stratum corneum lipids: Isothermal titration calorimetry study
Authors: Kang, L. 
Ho, P.C. 
Chan, S.Y. 
Keywords: Ceramide
Cholesterol
Free fatty acid
ITC
Laurocapram
Stratum corneum
Issue Date: Jan-2006
Citation: Kang, L., Ho, P.C., Chan, S.Y. (2006-01). Interactions between a skin penetration enhancer and the main components of human stratum corneum lipids: Isothermal titration calorimetry study. Journal of Thermal Analysis and Calorimetry 83 (1) : 27-30. ScholarBank@NUS Repository. https://doi.org/10.1007/s10973-005-7050-8
Abstract: The study employed isothermal titration calorimetry (ITC) technique to investigate the interactions between a skin penetration enhancer, laurocapram, and three representatives of the human stratum corneum (SC) intercellular lipids, i.e., ceramide-3, cholesterol and behenic acid. Experiments were performed using a TAM2277 (Thermometric AB, Sweden) calorimeter. Results showed that, firstly, two laurocapram molecules were bound to one ceramide-3 molecule in propylene glycol solution. The binding was enthalpy-driven and system entropy decreased after binding. Secondly, the binding ratio between cholesterol and laurocapram molecule was one to one. It was mainly an entropy-driven process, suggesting the ordered cholesterol molecules in SC lamella were disturbed by the introduction of laurocapram. Hydrogen bonding might be the main force of the binding. The three different interaction modes showed that the chemical enhancers selectively interacted with the components of SC lipids so that the SC can still retain its barrier function. © 2006 Akadémiai Kiadó.
Source Title: Journal of Thermal Analysis and Calorimetry
URI: http://scholarbank.nus.edu.sg/handle/10635/106075
ISSN: 13886150
DOI: 10.1007/s10973-005-7050-8
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

14
checked on Sep 17, 2019

WEB OF SCIENCETM
Citations

12
checked on Sep 10, 2019

Page view(s)

42
checked on Sep 7, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.