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Title: Insights into the functionality of pelletization aid in pelletization by extrusion-spheronization
Authors: Sarkar, S.
Heng, P.W.S. 
Liew, C.V. 
Keywords: Cross-linked polyvinyl pyrrolidone
In-process particle
Individual particle
Microcrystalline cellulose
Issue Date: Feb-2013
Citation: Sarkar, S., Heng, P.W.S., Liew, C.V. (2013-02). Insights into the functionality of pelletization aid in pelletization by extrusion-spheronization. Pharmaceutical Development and Technology 18 (1) : 61-72. ScholarBank@NUS Repository.
Abstract: This study investigated the particle sizes of pelletization aids from the different wet processing steps of extrusion-spheronization, and their influence on rheological and pellet properties. Three commercial microcrystalline cellulose (MCC) grades, three commercial cross-linked polyvinyl pyrrolidone (X-PVP) grades and two agglomerated X-PVP grades (prepared using roller compaction from two commercial fine particle size X-PVP grades) were used as pelletization aid. The pelletization aids were analyzed for their dry state particle size, individual particle size (sonicated powder dispersion in water) and in-process particle sizes (dispersions of processed materials from the different processing steps). No remarkable particle size changes were observed with the commercial X-PVP grades under the different conditions. The two fine X-PVP grades, but not the coarse grade, produced good quality pellets. MCC and agglomerated X-PVP grades exhibited spectacularly lower individual and in-process particle sizes, and produced good quality pellets although some of them had dry state particle sizes comparable to that of the commercial coarse X-PVP grade. In-process particle sizes of pelletization aids correlated strongly with the rheological and pellet properties of the pelletization aid:lactose (1:3) binary mixtures. These results demonstrated that small in-process particle size of pelletization aid is a critical requirement for successful pelletization by extrusion-spheronization. © 2013 Informa Healthcare USA, Inc.
Source Title: Pharmaceutical Development and Technology
ISSN: 10837450
DOI: 10.3109/10837450.2011.621210
Appears in Collections:Staff Publications

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