Please use this identifier to cite or link to this item:
Title: Insights into the functionality of pelletization aid in pelletization by extrusion-spheronization
Authors: Sarkar, S.
Heng, P.W.S. 
Liew, C.V. 
Keywords: Cross-linked polyvinyl pyrrolidone
In-process particle
Individual particle
Microcrystalline cellulose
Issue Date: Feb-2013
Citation: Sarkar, S., Heng, P.W.S., Liew, C.V. (2013-02). Insights into the functionality of pelletization aid in pelletization by extrusion-spheronization. Pharmaceutical Development and Technology 18 (1) : 61-72. ScholarBank@NUS Repository.
Abstract: This study investigated the particle sizes of pelletization aids from the different wet processing steps of extrusion-spheronization, and their influence on rheological and pellet properties. Three commercial microcrystalline cellulose (MCC) grades, three commercial cross-linked polyvinyl pyrrolidone (X-PVP) grades and two agglomerated X-PVP grades (prepared using roller compaction from two commercial fine particle size X-PVP grades) were used as pelletization aid. The pelletization aids were analyzed for their dry state particle size, individual particle size (sonicated powder dispersion in water) and in-process particle sizes (dispersions of processed materials from the different processing steps). No remarkable particle size changes were observed with the commercial X-PVP grades under the different conditions. The two fine X-PVP grades, but not the coarse grade, produced good quality pellets. MCC and agglomerated X-PVP grades exhibited spectacularly lower individual and in-process particle sizes, and produced good quality pellets although some of them had dry state particle sizes comparable to that of the commercial coarse X-PVP grade. In-process particle sizes of pelletization aids correlated strongly with the rheological and pellet properties of the pelletization aid:lactose (1:3) binary mixtures. These results demonstrated that small in-process particle size of pelletization aid is a critical requirement for successful pelletization by extrusion-spheronization. © 2013 Informa Healthcare USA, Inc.
Source Title: Pharmaceutical Development and Technology
ISSN: 10837450
DOI: 10.3109/10837450.2011.621210
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Jun 14, 2021


checked on Jun 14, 2021

Page view(s)

checked on Jun 7, 2021

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.