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Title: Influences of Osmotic Agents in Diffusion Layer on Drug Release from Multilayer Coated Pellets
Authors: Heng, P.W.S. 
Hao, J. 
Chan, L.W. 
Chew, S.H.
Keywords: Drug release
Multilayer coating
Osmotic agent
Issue Date: 2004
Citation: Heng, P.W.S., Hao, J., Chan, L.W., Chew, S.H. (2004). Influences of Osmotic Agents in Diffusion Layer on Drug Release from Multilayer Coated Pellets. Drug Development and Industrial Pharmacy 30 (2) : 213-220. ScholarBank@NUS Repository.
Abstract: Nonpareil beads were coated with three different functional layers, namely inner chlorpheniramine maleate-loaded hydroxypropylmethylcellulose (HPMC, 4 mPa·s) deposition layer, middle HPMC (400 mPa·s) diffusion layer, and outer polyacrylic polymer (Eudragit RS30D) retention layer. The osmotic agents, including sodium chloride, glycine, citric acid, and disodium hydrogen phosphate, were incorporated in different amounts into the diffusion layer and the influences on drug release were studied. The osmotic agent competed with HPMC for imbibed water and subsequently caused more water influx owing to the osmotic pressure gradient. An appropriate amount of osmotic agent in the diffusion layer was necessary to exert its effect on retarding drug release. The osmotic effect on drug release was compromised with pellets at a higher coating level of the diffusion layer due to the extensive swelling and rupture of coat. The release parameters, including dissolution T50% and mean dissolution time, showed linear relationship with osmolalities of osmotic agents studied. The effect of the osmotic agent in the diffusion layer played an important role in determining the unique multiphase drug release profiles, particularly in the initial phase of dissolution, and reduced with depletion of the osmotic agent in the later phase of dissolution.
Source Title: Drug Development and Industrial Pharmacy
ISSN: 03639045
DOI: 10.1081/DDC-120028717
Appears in Collections:Staff Publications

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