Please use this identifier to cite or link to this item: https://doi.org/10.1208/s12249-013-0031-5
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dc.titleInfluence of starting material particle size on pellet surface roughness
dc.contributor.authorSarkar, S.
dc.contributor.authorAng, B.H.
dc.contributor.authorLiew, C.V.
dc.date.accessioned2014-10-29T01:54:21Z
dc.date.available2014-10-29T01:54:21Z
dc.date.issued2014-02
dc.identifier.citationSarkar, S., Ang, B.H., Liew, C.V. (2014-02). Influence of starting material particle size on pellet surface roughness. AAPS PharmSciTech 15 (1) : 131-139. ScholarBank@NUS Repository. https://doi.org/10.1208/s12249-013-0031-5
dc.identifier.issn15309932
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/106054
dc.description.abstractThe purpose of this study was to investigate the effect of pelletization aids, i.e., microcrystalline cellulose (MCC) and cross-linked polyvinyl pyrrolidone (XPVP), and filler, i.e., lactose, particle size on the surface roughness of pellets. Pellets were prepared from powder blends containing pelletization aid/lactose in 1:3 ratio by extrusion-spheronization. Surface roughness of pellets was assessed quantitatively and qualitatively using optical interferometry and scanning electron microscopy, respectively. Both quantitative and qualitative surface studies showed that surface roughness of pellets depended on the particle size of XPVP and lactose used in the formulation. Increase in XPVP or lactose particle size resulted in rougher pellets. Formulations containing MCC produced pellets with smoother surfaces than those containing XPVP. Furthermore, surface roughness of the resultant pellets did not appear to depend on MCC particle size. Starting material particle size was found to be a critical factor for determining the surface roughness of pellets produced by extrusion-spheronization. Smaller particles can pack well with lower peaks and valleys, resulting in pellets with smoother surfaces. Similar surface roughness of pellets containing different MCC grades could be due to the deaggregation of MCC particles into smaller subunits with more or less similar sizes during wet processing. Hence, for starting materials that deaggregate during the wet processing, pellet surface roughness is influenced by the particle size of the material upon deaggregation. © 2013 American Association of Pharmaceutical Scientists.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1208/s12249-013-0031-5
dc.sourceScopus
dc.subjectextrusion-spheronization
dc.subjectfiller
dc.subjectparticle size
dc.subjectpelletization aid
dc.subjectsurface roughness
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1208/s12249-013-0031-5
dc.description.sourcetitleAAPS PharmSciTech
dc.description.volume15
dc.description.issue1
dc.description.page131-139
dc.identifier.isiut000334053200015
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