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Title: In vitro metabolism of leflunomide by mouse and human liver microsomes.
Authors: Chan, E.C. 
New, L.S. 
Issue Date: Dec-2007
Citation: Chan, E.C.,New, L.S. (2007-12). In vitro metabolism of leflunomide by mouse and human liver microsomes.. Drug metabolism letters 1 (4) : 299-305. ScholarBank@NUS Repository.
Abstract: Leflunomide was found to be metabolized predominantly to A77-1726 and two novel hydroxylated metabolites, M1 and M2, in microsomes while A77-1726 was only biotransformed to M1. M1 and M2 were proposed to be the hydroxylated alpha-cyanoenol form of A77-1726 and the hydroxylated 5 methyl-isoxazole form of leflunomide, respectively.
Source Title: Drug metabolism letters
ISSN: 18723128
DOI: 10.2174/187231207783221402
Appears in Collections:Staff Publications

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