Please use this identifier to cite or link to this item:
|Title:||Formation of alginate microspheres produced using emulsification technique||Authors:||Heng, P.W.S.
|Issue Date:||May-2003||Citation:||Heng, P.W.S., Chan, L.W., Wong, T.W. (2003-05). Formation of alginate microspheres produced using emulsification technique. Journal of Microencapsulation 20 (3) : 401-413. ScholarBank@NUS Repository. https://doi.org/10.1080/0265204031000093069||Abstract:||This study investigated the formative process of alginate microspheres produced using an emulsification technique. The alginate microspheres were produced by cross-linking alginate globules dispersed in a continuous organic phase using various calcium salts: calcium chloride, calcium acetate, calcium lactate and calcium gluconate. The size, shape, drug content and Ca2+ content of the microspheres were evaluated. The tack, viscosity and pH of the calcium salt solution and percentage of Ca2+ partitioned into the organic phase were determined. Microscopic examination of the test emulsion at various stages of the emulsification process was also carried out. The propensity of cross-linking reaction was found to be dependent on successful collision between alginate and calcium salt globules. Examination of the characteristics of microspheres indicated that the formed microsphere was a resultant product of alginate globule clustering. The growth propensity of microspheres was promoted by the higher rate and extent of cross-linkage which was governed by the pH, tack and/or Ca2+ content of the cross-linking solution, as well as the dissociation constant and diffusivity of the calcium salt. Overall, the amount of free Ca2+ cross-linked with alginate in the formed microspheres was in the following order: calcium acetate > calcium chloride + calcium acetate > calcium chloride + calcium gluconate; calcium chloride + calcium lactate > calcium chloride. In microencapsulation by emulsification, the mean size of the microspheres produced can be modified by varying the tack, pH and Ca2+ content of the cross-linking solution and through the use of a combination of calcium salts. The shape of the microspheres produced was, nonetheless, unaffected by the physicochemical properties of the cross-linking solution.||Source Title:||Journal of Microencapsulation||URI:||http://scholarbank.nus.edu.sg/handle/10635/105961||ISSN:||02652048||DOI:||10.1080/0265204031000093069|
|Appears in Collections:||Staff Publications|
Show full item record
Files in This Item:
There are no files associated with this item.
checked on Sep 22, 2020
WEB OF SCIENCETM
checked on Sep 22, 2020
checked on Sep 26, 2020
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.