Please use this identifier to cite or link to this item: https://doi.org/10.1080/10837450600561240
DC FieldValue
dc.titleFeasibility of eliminating premixing for the production of pellets in a rotary processor
dc.contributor.authorGu, L.
dc.contributor.authorLiew, C.V.
dc.contributor.authorSoh, J.L.P.
dc.contributor.authorHeng, P.W.S.
dc.date.accessioned2014-10-29T01:53:01Z
dc.date.available2014-10-29T01:53:01Z
dc.date.issued2006-05
dc.identifier.citationGu, L., Liew, C.V., Soh, J.L.P., Heng, P.W.S. (2006-05). Feasibility of eliminating premixing for the production of pellets in a rotary processor. Pharmaceutical Development and Technology 11 (2) : 159-165. ScholarBank@NUS Repository. https://doi.org/10.1080/10837450600561240
dc.identifier.issn10837450
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105958
dc.description.abstractThis current study aims to explore the feasibility of eliminating the premixing step for making pellets in a rotary processor. Microcrystalline cellulose (MCC) and lactose were used as starting materials. They could be loaded into the rotary processor separately using three different loading configurations (Methods I, II, and III) or as MCC:lactose blend, which was prepared in the separate mixer prior to loading (Method IV). Physical properties of the pellets prepared in Methods I-III were evaluated and compared against those prepared using a premixed blend (Method IV). The effects of loading configuration on pellet quality can be assessed by comparing the pellets prepared in Methods I, II, and III. Physical characterization of pellets included mean size, size distribution, oversized fraction, and shape. No significant difference in pellet properties could be attributed to the effect of premixing. Pellet properties were not significantly affected by the different loading configurations either. This study demonstrated that homogeneous powder blends are not required for the production of pellets in rotary processing. The tumbling action of the powders at the start of rotary processing is sufficient to ensure adequate powder mixing. However, it may be judicious to co-feed the different powders to achieve some preliminary mixing during loading under extreme processing conditions. Copyright © Taylor & Francis Group, LLC.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1080/10837450600561240
dc.sourceScopus
dc.subjectLoading configurations
dc.subjectMicrocrystalline cellulose
dc.subjectPelletization
dc.subjectPremixing
dc.subjectRotary processor
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1080/10837450600561240
dc.description.sourcetitlePharmaceutical Development and Technology
dc.description.volume11
dc.description.issue2
dc.description.page159-165
dc.description.codenPDTEF
dc.identifier.isiut000237623800002
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