Dual-functionalized PAMAM dendrimers with improved P-glycoprotein inhibition and tight junction modulating effect

Please use this identifier to cite or link to this item: https://doi.org/10.1021/bm401057c

Title:	Dual-functionalized PAMAM dendrimers with improved P-glycoprotein inhibition and tight junction modulating effect
Authors:	Liu, Y. Chiu, G.N.C.
Issue Date:	9-Dec-2013
Citation:	Liu, Y., Chiu, G.N.C. (2013-12-09). Dual-functionalized PAMAM dendrimers with improved P-glycoprotein inhibition and tight junction modulating effect. Biomacromolecules 14 (12) : 4226-4235. ScholarBank@NUS Repository. https://doi.org/10.1021/bm401057c
Abstract:	This study aims to surface modify poly(amido amine) or PAMAM dendrimers by sequentially grafting poly(ethylene glycol) or PEG and 4-thiobutylamidine (TBA) so as to reduce PAMAM cytotoxicity while improving the ability of PAMAM to modulate P-glycoprotein (P-gp) efflux and tight junction integrity. Conjugation of functional groups was determined by NMR spectroscopy, FT-IR, thiol group quantification and molecular weight estimation. The yield of the dual-functionalized dendrimers was >80%. The dual-functionalized dendrimer could significantly reduce PAMAM cytotoxicity to
Source Title:	Biomacromolecules
URI:	http://scholarbank.nus.edu.sg/handle/10635/105861
ISSN:	15257797
DOI:	10.1021/bm401057c
Appears in Collections:	Staff Publications

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