Please use this identifier to cite or link to this item: https://doi.org/10.1021/bm401057c
Title: Dual-functionalized PAMAM dendrimers with improved P-glycoprotein inhibition and tight junction modulating effect
Authors: Liu, Y.
Chiu, G.N.C. 
Issue Date: 9-Dec-2013
Citation: Liu, Y., Chiu, G.N.C. (2013-12-09). Dual-functionalized PAMAM dendrimers with improved P-glycoprotein inhibition and tight junction modulating effect. Biomacromolecules 14 (12) : 4226-4235. ScholarBank@NUS Repository. https://doi.org/10.1021/bm401057c
Abstract: This study aims to surface modify poly(amido amine) or PAMAM dendrimers by sequentially grafting poly(ethylene glycol) or PEG and 4-thiobutylamidine (TBA) so as to reduce PAMAM cytotoxicity while improving the ability of PAMAM to modulate P-glycoprotein (P-gp) efflux and tight junction integrity. Conjugation of functional groups was determined by NMR spectroscopy, FT-IR, thiol group quantification and molecular weight estimation. The yield of the dual-functionalized dendrimers was >80%. The dual-functionalized dendrimer could significantly reduce PAMAM cytotoxicity to
Source Title: Biomacromolecules
URI: http://scholarbank.nus.edu.sg/handle/10635/105861
ISSN: 15257797
DOI: 10.1021/bm401057c
Appears in Collections:Staff Publications

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