Please use this identifier to cite or link to this item: https://doi.org/10.1002/jps.21872
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dc.titleDielectric properties of pharmaceutical materials relevant to microwave processing: Effects of field frequency, material density, and moisture content
dc.contributor.authorHeng, P.W.S.
dc.contributor.authorLoh, Z.H.
dc.contributor.authorLiew, C.V.
dc.contributor.authorLee, C.C.
dc.date.accessioned2014-10-29T01:51:18Z
dc.date.available2014-10-29T01:51:18Z
dc.date.issued2010-02
dc.identifier.citationHeng, P.W.S., Loh, Z.H., Liew, C.V., Lee, C.C. (2010-02). Dielectric properties of pharmaceutical materials relevant to microwave processing: Effects of field frequency, material density, and moisture content. Journal of Pharmaceutical Sciences 99 (2) : 941-957. ScholarBank@NUS Repository. https://doi.org/10.1002/jps.21872
dc.identifier.issn00223549
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105833
dc.description.abstractThe rising popularity of microwaves for drying, material processing and quality sensing has fuelled the need for knowledge concerning dielectric properties of common pharmaceutical materials. This article represents one of the few reports on the density and moisture content dependence of the dielectric properties of primary pharmaceutical materials and their relevance to microwave-assisted processing. Dielectric constants (ε′) and losses (ε″) of 13 pharmaceutical materials were measured over a frequency range of 1 MHz-1GHz at 23±1°C using a parallel-electrode measurement system. Effects of field frequency, material density and moisture content on dielectric properties were studied. Material dielectric properties varied considerably with frequency. At microwave frequencies, linear relationships were established between cube-root functions of the dielectric parameters ( 3√ε′ and 3√ε″) and density which enabled dielectric properties of materials at various densities to be estimated by regression. Moisture content was the main factor that contributed to the disparities in dielectric properties and heating capabilities of the materials in a laboratory microwave oven. The effectiveness of a single frequency density-independent dielectric function for moisture sensing applications was explored and found to be suitable within low ranges of moisture contents for a model material. © 2009 Wiley-Liss, Inc. and the American Pharmacists Association.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1002/jps.21872
dc.sourceScopus
dc.subjectCompaction
dc.subjectDielectric properties
dc.subjectExcipients
dc.subjectMicrowave frequency
dc.subjectPhysical characterization
dc.subjectPowder technology
dc.subjectPreformulation
dc.subjectProcessing
dc.subjectSolid state
dc.subjectWater in solids
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1002/jps.21872
dc.description.sourcetitleJournal of Pharmaceutical Sciences
dc.description.volume99
dc.description.issue2
dc.description.page941-957
dc.description.codenJPMSA
dc.identifier.isiut000274114100035
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