Please use this identifier to cite or link to this item: https://doi.org/10.1248/cpb.56.1459
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dc.titleCytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos
dc.contributor.authorZhou, L.
dc.contributor.authorZhang, Y.
dc.contributor.authorGapter, L.A.
dc.contributor.authorLing, H.
dc.contributor.authorAgarwal, R.
dc.contributor.authorNg, K.-Y.
dc.date.accessioned2014-10-29T01:50:44Z
dc.date.available2014-10-29T01:50:44Z
dc.date.issued2008-10
dc.identifier.citationZhou, L., Zhang, Y., Gapter, L.A., Ling, H., Agarwal, R., Ng, K.-Y. (2008-10). Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. Chemical and Pharmaceutical Bulletin 56 (10) : 1459-1462. ScholarBank@NUS Repository. https://doi.org/10.1248/cpb.56.1459
dc.identifier.issn00092363
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105790
dc.description.abstractA new lanostane-type triterpene, 29-hydroxypolyporenic acid C (8), was isolated from the dried sclerotia of Poria cocos together with eight other known compounds pachymic acid (1), dehydropachymic acid (2), 3-acetyloxy-16α- hydroxytrametenolic acid (3), polyporenic acid C (4), 3-epi-dehydropachymic acid (5), 3-epi-dehydrotumulosic acid (6), tumulosic acid (7), and dehydrotumulosic acid (9). The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. Although none of the nine (1 to 9) compounds showed promising antioxidant activity, 1 through 6 and 8 showed good cytotoxicity against human lung cancer cell line A549 and human prostate cancer cell line DU145. Interestingly, all these compounds exhibited better cytotoxicity towards A549 than DU145 cells. © 2008 Pharmaceutical Society of Japan.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1248/cpb.56.1459
dc.sourceScopus
dc.subjectAntioxidant
dc.subjectCytotoxicity
dc.subjectLanostane
dc.subjectPhytochemistry
dc.subjectPoria cocos
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1248/cpb.56.1459
dc.description.sourcetitleChemical and Pharmaceutical Bulletin
dc.description.volume56
dc.description.issue10
dc.description.page1459-1462
dc.description.codenCPBTA
dc.identifier.isiut000259672800017
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