Please use this identifier to cite or link to this item: https://doi.org/10.1248/cpb.56.1459
Title: Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos
Authors: Zhou, L. 
Zhang, Y.
Gapter, L.A. 
Ling, H.
Agarwal, R.
Ng, K.-Y. 
Keywords: Antioxidant
Cytotoxicity
Lanostane
Phytochemistry
Poria cocos
Issue Date: Oct-2008
Citation: Zhou, L., Zhang, Y., Gapter, L.A., Ling, H., Agarwal, R., Ng, K.-Y. (2008-10). Cytotoxic and anti-oxidant activities of lanostane-type triterpenes isolated from Poria cocos. Chemical and Pharmaceutical Bulletin 56 (10) : 1459-1462. ScholarBank@NUS Repository. https://doi.org/10.1248/cpb.56.1459
Abstract: A new lanostane-type triterpene, 29-hydroxypolyporenic acid C (8), was isolated from the dried sclerotia of Poria cocos together with eight other known compounds pachymic acid (1), dehydropachymic acid (2), 3-acetyloxy-16α- hydroxytrametenolic acid (3), polyporenic acid C (4), 3-epi-dehydropachymic acid (5), 3-epi-dehydrotumulosic acid (6), tumulosic acid (7), and dehydrotumulosic acid (9). The compounds were identified by spectral analysis and comparison with spectroscopic data reported in the literatures. Although none of the nine (1 to 9) compounds showed promising antioxidant activity, 1 through 6 and 8 showed good cytotoxicity against human lung cancer cell line A549 and human prostate cancer cell line DU145. Interestingly, all these compounds exhibited better cytotoxicity towards A549 than DU145 cells. © 2008 Pharmaceutical Society of Japan.
Source Title: Chemical and Pharmaceutical Bulletin
URI: http://scholarbank.nus.edu.sg/handle/10635/105790
ISSN: 00092363
DOI: 10.1248/cpb.56.1459
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

68
checked on Aug 13, 2019

WEB OF SCIENCETM
Citations

60
checked on Aug 6, 2019

Page view(s)

56
checked on Aug 16, 2019

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.