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Title: Cutaneous reaction associated with weekly docetaxel administration
Authors: Chew, L. 
Chuen, V.S.L.
Keywords: Cutaneous reaction
Skin toxicity
Issue Date: 2009
Citation: Chew, L.,Chuen, V.S.L. (2009). Cutaneous reaction associated with weekly docetaxel administration. Journal of Oncology Pharmacy Practice 15 (1) : 29-34. ScholarBank@NUS Repository.
Abstract: Background. Docetaxel-based chemotherapy will remain clinically relevant and many of our patients will continue to receive the drug. In a recent phase 2 study of docetaxel 35 mg/m2 (weekly) in patients with metastatic breast cancer, the incidence of grade 3 cutaneous toxicity is 19%. The skin toxicity observed consists of limb/palmar-plantar erythematous reactions, or fixed-plaque erythrodysesthesia. Case series or reports have reported varied manifestations of skin reactions and include erythema multiforme, nail changes (onycholysis, pigmentation, paronychia), scleroderma, supravenous discoloration, radiation recall dermatitis, and flagellate erythema. Method. We would like to report four patients with cutaneous reactions resulting from weekly administration of docetaxel. Results. All cases are heavily pre-treated patients, receiving docetaxel as second or third line therapy. The cutaneous reactions occur at cycle 5. The time between chemotherapy to development of skin lesions is from 1 to 7 days. Lesions usually resolve with desquamation leaving behind areas with hyper-pigmentation or hypo-pigmentation over a period of 2 to 3 weeks. The management strategies include hand elevation, warm or cold compresses, topical and/or systemic antibiotics, topical and/or systemic corticosteroids, and cessation of drug. Conclusions. There is a need for a systematic approach to manage these cutaneous reactions. Oncology trained pharmacists play vital roles in assessing, managing, documenting and patient education. © 2009 SAGE Publications.
Source Title: Journal of Oncology Pharmacy Practice
ISSN: 10781552
DOI: 10.1177/1078155208096111
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