Please use this identifier to cite or link to this item: https://doi.org/10.1073/pnas.1107336108
DC FieldValue
dc.titleClustered patterns of species origins of nature-derived drugs and clues for future bioprospecting
dc.contributor.authorZhu, F.
dc.contributor.authorQin, C.
dc.contributor.authorTao, L.
dc.contributor.authorLiu, X.
dc.contributor.authorShi, Z.
dc.contributor.authorMa, X.
dc.contributor.authorJia, J.
dc.contributor.authorTan, Y.
dc.contributor.authorCui, C.
dc.contributor.authorLin, J.
dc.contributor.authorTan, C.
dc.contributor.authorJiang, Y.
dc.contributor.authorChen, Y.
dc.date.accessioned2014-10-29T01:50:02Z
dc.date.available2014-10-29T01:50:02Z
dc.date.issued2011-08-02
dc.identifier.citationZhu, F., Qin, C., Tao, L., Liu, X., Shi, Z., Ma, X., Jia, J., Tan, Y., Cui, C., Lin, J., Tan, C., Jiang, Y., Chen, Y. (2011-08-02). Clustered patterns of species origins of nature-derived drugs and clues for future bioprospecting. Proceedings of the National Academy of Sciences of the United States of America 108 (31) : 12943-12948. ScholarBank@NUS Repository. https://doi.org/10.1073/pnas.1107336108
dc.identifier.issn00278424
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105742
dc.description.abstractMany drugs are nature derived. Lowdrug productivity has renewed interest in natural products as drug-discovery sources. Naturederived drugs are composed of dozens of molecular scaffolds generated by specific secondary-metabolite gene clusters in selected species. It can be hypothesized that drug-like structures probably are distributed in selective groups of species. We compared the species origins of 939 approved and 369 clinical-trial drugs with those of 119 preclinical drugs and 19,721 bioactive natural products. In contrast to the scattered distribution of bioactive natural products, these drugs are clustered into 144 of the 6,763 known species families in nature, with 80% of the approved drugs and 67% of the clinical-trial drugs concentrated in 17 and 30 drug-prolific families, respectively. Four lines of evidence from historical drug data, 13,548 marine natural products, 767medicinal plants, and19,721 bioactive natural products suggest that drugs are derived mostly from preexisting drugproductive families. Drug-productive clusters expand slowly by conventional technologies. The lack of drugs outside drug-productive families is not necessarily the result of under-exploration or late exploration by conventional technologies. New technologies that explore cryptic gene clusters, pathways, interspecies crosstalk, and high-throughput fermentation enable the discovery of novel natural products. The potential impact of these technologies on drug productivity and on the distribution patterns of drug-productive families is yet to be revealed.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1073/pnas.1107336108
dc.sourceScopus
dc.subjectBiodiversity
dc.subjectDrug-prolific species
dc.subjectHerb
dc.subjectPhylogenetic tree
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1073/pnas.1107336108
dc.description.sourcetitleProceedings of the National Academy of Sciences of the United States of America
dc.description.volume108
dc.description.issue31
dc.description.page12943-12948
dc.description.codenPNASA
dc.identifier.isiut000293385700079
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