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Title: Chitosan microspheres prepared by emulsification and ionotropic gelation
Authors: Lim, L.Y. 
Wan, L.S.C. 
Thai, P.Y.
Issue Date: 1997
Citation: Lim, L.Y.,Wan, L.S.C.,Thai, P.Y. (1997). Chitosan microspheres prepared by emulsification and ionotropic gelation. Drug Development and Industrial Pharmacy 23 (10) : 981-985. ScholarBank@NUS Repository.
Abstract: An attempt was made to prepare chitosan microspheres by an emulsion-phase separation technique but without the usual use of glutaraldehyde as a cross-linking agent. Instead, ionotropic gelation was employed in a w/o emulsion. The effect of formation factors was examined. The results showed that microspheres so formed were spherical, free-flowing, and had smooth surfaces. The rate of addition of counterions was important. Gelation of chitosan droplets should take place before the destabilizing effect of the counterions occurred. This effect is associated with the increase in aqueous phase volume when the counterion solution is incorporated.
Source Title: Drug Development and Industrial Pharmacy
ISSN: 03639045
Appears in Collections:Staff Publications

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