Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.jep.2009.07.038
Title: Antiplatelet and anticoagulant effects of Panax notoginseng: Comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium
Authors: Lau, A.-J. 
Toh, D.-F. 
Chua, T.-K.
Pang, Y.-K.
Woo, S.-O.
Koh, H.-L. 
Keywords: Anticoagulation
Antiplatelet
Bleeding time
Panax ginseng
Panax notoginseng
Panax quinquefolium
Issue Date: 25-Sep-2009
Citation: Lau, A.-J., Toh, D.-F., Chua, T.-K., Pang, Y.-K., Woo, S.-O., Koh, H.-L. (2009-09-25). Antiplatelet and anticoagulant effects of Panax notoginseng: Comparison of raw and steamed Panax notoginseng with Panax ginseng and Panax quinquefolium. Journal of Ethnopharmacology 125 (3) : 380-386. ScholarBank@NUS Repository. https://doi.org/10.1016/j.jep.2009.07.038
Abstract: Ethnopharmacological significance: Panax notoginseng (Burk.) F. H. Chen (Araliacea) is traditionally used for its hemostatic and cardiovascular effects when raw and as a tonic when steamed. Aim of the study: This study aims to compare the effects of raw and steamed Panax notoginseng, Panax ginseng C. A. Meyer and Panax quinquefolium Linn. on platelet aggregation and plasma coagulation. Materials and methods: Effects on collagen-induced platelet aggregation were investigated using a platelet aggregometer, while the plasma coagulation times (prothrombin time, activated partial thromboplastin time and thrombin time) were determined using a blood coagulation analyzer. The data was corroborated with ex vivo platelet aggregation and in vivo rat bleeding time. Results: Raw and steamed Panax notoginseng significantly inhibit platelet aggregation and plasma coagulation. Steamed Panax notoginseng has significantly more potent antiplatelet and anticoagulant effects than the raw extract, and the antiplatelet and anticoagulant effects increase with increasing steaming durations. Comparing the three common Panax species, Panax notoginseng has higher antiplatelet effect than Panax ginseng and Panax quinquefolium. The in vitro antiplatelet and anticoagulant effects are positively translated into a prolongation of in vivo rat bleeding time after oral administration of the raw and steamed extracts. Conclusion: The results indicate that the three common Panax species affect platelet aggregation and plasma coagulation differently, with steamed Panax notoginseng showing the greatest antiplatelet and anticoagulant effects. Panax notoginseng may be a good source of lead compounds for novel antiplatelet and anticoagulant therapeutics. © 2009 Elsevier Ireland Ltd. All rights reserved.
Source Title: Journal of Ethnopharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/105659
ISSN: 03788741
DOI: 10.1016/j.jep.2009.07.038
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

99
checked on Mar 30, 2020

WEB OF SCIENCETM
Citations

86
checked on Mar 30, 2020

Page view(s)

96
checked on Mar 28, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.