Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.fct.2013.05.058
Title: Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury
Authors: Zhang, Y.-C.
Gan, F.-F. 
Shelar, S.B.
Ng, K.-Y. 
Chew, E.-H. 
Keywords: Antioxidant activity
Ixeris sonchifolia Hance
Luteolin
Middle cerebral artery occlusion
Neuroprotection
Nrf2 induction
Issue Date: Sep-2013
Citation: Zhang, Y.-C., Gan, F.-F., Shelar, S.B., Ng, K.-Y., Chew, E.-H. (2013-09). Antioxidant and Nrf2 inducing activities of luteolin, a flavonoid constituent in Ixeris sonchifolia Hance, provide neuroprotective effects against ischemia-induced cellular injury. Food and Chemical Toxicology 59 : 272-280. ScholarBank@NUS Repository. https://doi.org/10.1016/j.fct.2013.05.058
Abstract: Ixeris sonchifolia Hance is an herb distributed in northeastern part of China and has been used by natives to invigorate circulation. In the present study, bioactivity-guided fractionation of I. sonchifolia Hance extract was performed with the aim to isolate and identify the compounds underlying the potential protective effects against ischemia brain injury. Among the four fractions isolated from the herb extract, the ethyl acetate fraction was found to scavenge DPPH radicals, induce ARE-dependent transcriptional activity and upregulate Nrf2 protein levels. The isolation work focused on this fraction revealed the presence of two categories of compounds: flavonoids and sesquiterpene lactones. Among the five isolated flavonoids, luteolin was evaluated to possess direct and indirect antioxidant activities by scavenging free radicals and inducing the upregulation of ARE-dependent phase II enzymes. Concomitant with the findings from the cell-based assays, in the middle cerebral artery occlusion-induced ischemia rat model, administration of luteolin at 4. mg/kg displayed neuroprotective effects by reducing infarct area and inhibiting neuronal cell death. In summary, the obtained results suggest that flavonoids in I. sonchifolia Hance, in particular luteolin, contribute at least partly to the neuroprotective effects against ischemia-induced cellular injury and can be potentially developed for treatment of ischemia-reperfusion induced diseases. © 2013 Elsevier Ltd.
Source Title: Food and Chemical Toxicology
URI: http://scholarbank.nus.edu.sg/handle/10635/105657
ISSN: 02786915
DOI: 10.1016/j.fct.2013.05.058
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