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Title: Anti-inflammatory components isolated from Atractylodes macrocephala Koidz
Authors: Dong, H.
He, L.
Huang, M. 
Dong, Y.
Keywords: 14-acetoxy-12-α-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol
Anti-inflammatory effects
Atractylenolide I
Atractylenolide III
Atractylodis macrocephalae
Issue Date: 10-Nov-2008
Citation: Dong, H., He, L., Huang, M., Dong, Y. (2008-11-10). Anti-inflammatory components isolated from Atractylodes macrocephala Koidz. Natural Product Research 22 (16) : 1418-1427. ScholarBank@NUS Repository.
Abstract: The petroleum ether-ether (1:1) extract of Atractylodis macrocephalae was screened by cell membrane chromatography (CMC) and subsequently separated by column chromatography (CC) and high performance liquid chromatography (HPLC). Five components were isolated and identified as atractylenolide III 1, atractylenolide I 2, 14-acetoxy-12-senecioyloxytetradeca-2E,8E,10E-trien-4,6-diyn-1-ol 3, 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 4 and 14-acetoxy-12-β-methylbutyl-2E,8E,10E-trien-4,6-diyn-1-ol 5 by routine spectrometric methods. The data of 5 and 13C-NMR data of 3 and 4 were reported for the first time. Further in vivo experiments showed that the five components exhibited significant inhibiting effects both on the ear edema induced by xylene and on the peritoneal capillary permeability induced by acetic acid in mice.
Source Title: Natural Product Research
ISSN: 14786419
DOI: 10.1080/14786410801931629
Appears in Collections:Staff Publications

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