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Title: Analysis of growth of granules in a fluidized bed granulator
Authors: Wan, L.S.C. 
Heng, P.W.S. 
Muhuri, G.
Issue Date: 1992
Citation: Wan, L.S.C.,Heng, P.W.S.,Muhuri, G. (1992). Analysis of growth of granules in a fluidized bed granulator. S.T.P. Pharma Sciences 2 (5) : 381-386. ScholarBank@NUS Repository.
Abstract: The growth of granules in a fluidized bed granulator depends primarily on the type and concentration of binder used and its distribution in the system. The growth of lactose granules was controlled by varying the concentration and spray rate of polyvinylpyrrolidone binder solution. The increase in concentration and volume of the binder solution increased the mean size of granules formed, but simultaneously decreased the mass flow rate. Granules prepared with a higher concentration and volume of polyvinylpyrrolidone were less cohesive than those prepared with a lower concentration and volume. Most of the feed material and fine products formed by the attrition of agglomerates was exhausted after spraying 75 and 90 ml of 5% polyvinylpyrrolidone solution. The sphericity of the granules further increased when a 100 ml polyvinylpyrrolidone solution was sprayed in the second stage, after the first-stage spraying of a 90 ml 5% polyvinylpyrrolidone solution.
Source Title: S.T.P. Pharma Sciences
ISSN: 11571489
Appears in Collections:Staff Publications

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