Please use this identifier to cite or link to this item: https://doi.org/10.1016/S0378-5173(00)00619-0
DC FieldValue
dc.titleAn improved method for the measurement of colour uniformity in pellet coating
dc.contributor.authorChan, L.W.
dc.contributor.authorChan, W.Y.
dc.contributor.authorHeng, P.W.S.
dc.date.accessioned2014-10-29T01:48:25Z
dc.date.available2014-10-29T01:48:25Z
dc.date.issued2001-02-01
dc.identifier.citationChan, L.W., Chan, W.Y., Heng, P.W.S. (2001-02-01). An improved method for the measurement of colour uniformity in pellet coating. International Journal of Pharmaceutics 213 (1-2) : 63-74. ScholarBank@NUS Repository. https://doi.org/10.1016/S0378-5173(00)00619-0
dc.identifier.issn03785173
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105639
dc.description.abstractSucrose pellets in the size range of 0.71-0.85 mm were film-coated in a bottom-spray Wurster fluidised bed coater with a colour coating suspension of 7.5% w/w solids. Hydroxypropyl methylcellulose was used as a film former, polyethylene glycol as a plasticiser and yellow iron oxide as a coloured pigment. The colour distribution on the film coat was analysed using a tristimulus colorimeter and the colour value was measured in CIELAB units. Uniformity in the colour coat was indicated by the standard deviation of the colour measurement values. Four different methods for measuring the colour distribution over the colour coated pellets' surfaces were carried out. In method I, colour measurements of the pellets' surfaces were made by placing the pellets directly on the stage of the tristimulus colorimeter. A specially designed pellet sample holder was employed to assist the collection of colour measurements in methods II-IV. Colour measurements from eight spots on each pellet were taken in methods I, II and IV while method III involved measuring 24 spots per pellet. A total of eight overlapping spot measurements were taken in method IV while the eight spot measurements in method II were non-overlapping. Method II was found to be the most efficient, accurate and sensitive method for the measurement of spot colour distribution on pellets. © 2001 Elsevier Science B.V.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1016/S0378-5173(00)00619-0
dc.sourceScopus
dc.subjectCIELAB units
dc.subjectCoating
dc.subjectColour uniformity
dc.subjectFluidised bed
dc.subjectTristimulus colorimeter
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1016/S0378-5173(00)00619-0
dc.description.sourcetitleInternational Journal of Pharmaceutics
dc.description.volume213
dc.description.issue1-2
dc.description.page63-74
dc.description.codenIJPHD
dc.identifier.isiut000166934100007
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

21
checked on Nov 24, 2020

WEB OF SCIENCETM
Citations

21
checked on Nov 24, 2020

Page view(s)

84
checked on Nov 22, 2020

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.