Please use this identifier to cite or link to this item: https://doi.org/10.1111/epi.12126
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dc.titleAdherence to antiepileptic medicines in children: A multiple-methods assessment involving dried blood spot sampling
dc.contributor.authorShah, N.M.
dc.contributor.authorHawwa, A.F.
dc.contributor.authorMillership, J.S.
dc.contributor.authorCollier, P.S.
dc.contributor.authorHo, P.
dc.contributor.authorTan, M.L.
dc.contributor.authorPeake, D.
dc.contributor.authorTirupathi, S.
dc.contributor.authorBothwell, J.
dc.contributor.authorBailie, N.
dc.contributor.authorShepherd, C.
dc.contributor.authorCraig, J.
dc.contributor.authorMcElnay, J.C.
dc.date.accessioned2014-10-29T01:48:13Z
dc.date.available2014-10-29T01:48:13Z
dc.date.issued2013-06
dc.identifier.citationShah, N.M., Hawwa, A.F., Millership, J.S., Collier, P.S., Ho, P., Tan, M.L., Peake, D., Tirupathi, S., Bothwell, J., Bailie, N., Shepherd, C., Craig, J., McElnay, J.C. (2013-06). Adherence to antiepileptic medicines in children: A multiple-methods assessment involving dried blood spot sampling. Epilepsia 54 (6) : 1020-1027. ScholarBank@NUS Repository. https://doi.org/10.1111/epi.12126
dc.identifier.issn00139580
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105620
dc.description.abstractSummary Purpose To evaluate adherence to prescribed antiepileptic drugs (AEDs) in children with epilepsy using a combination of adherence-assessment methods. Methods A total of 100 children with epilepsy (≤17 years old) were recruited. Medication adherence was determined via parental and child self-reporting (≥9 years old), medication refill data from general practitioner (GP) prescribing records, and via AED concentrations in dried blood spot (DBS) samples obtained from children at the clinic and via self- or parental-led sampling in children's own homes. The latter were assessed using population pharmacokinetic modeling. Patients were deemed nonadherent if any of these measures were indicative of nonadherence with the prescribed treatment. In addition, beliefs about medicines, parental confidence in seizure management, and the presence of depressed mood in parents were evaluated to examine their association with nonadherence in the participating children. Key Findings The overall rate of nonadherence in children with epilepsy was 33%. Logistic regression analysis indicated that children with generalized epilepsy (vs. focal epilepsy) were more likely (odds ratio [OR] 4.7, 95% confidence interval [CI] 1.37-15.81) to be classified as nonadherent as were children whose parents have depressed mood (OR 3.6, 95% CI 1.16-11.41). Significance This is the first study to apply the novel methodology of determining adherence via AED concentrations in clinic and home DBS samples. The present findings show that the latter, with further development, could be a useful approach to adherence assessment when combined with other measures including parent and child self-reporting. Seizure type and parental depressed mood were strongly predictive of nonadherence. © Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1111/epi.12126
dc.sourceScopus
dc.subjectAdherence
dc.subjectDepressed mood
dc.subjectDried blood spots
dc.subjectEpilepsy
dc.subjectMARS
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1111/epi.12126
dc.description.sourcetitleEpilepsia
dc.description.volume54
dc.description.issue6
dc.description.page1020-1027
dc.description.codenEPILA
dc.identifier.isiut000319873800010
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