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Title: A simple method of microneedle array fabrication for transdermal drug delivery
Authors: Kochhar, J.S.
Goh, W.J.
Chan, S.Y. 
Kang, L. 
Keywords: Microneedles
Transdermal drug delivery
Issue Date: Feb-2013
Citation: Kochhar, J.S., Goh, W.J., Chan, S.Y., Kang, L. (2013-02). A simple method of microneedle array fabrication for transdermal drug delivery. Drug Development and Industrial Pharmacy 39 (2) : 299-309. ScholarBank@NUS Repository.
Abstract: The outermost layer of skin, stratum corneum, being lipophilic limits the passive transport of hydrophilic and large molecular weight drugs. Microfabrication technology has been adapted to fabricate micron scale needles, which are minimally invasive, yet able to deliver the drugs across this barrier layer. In this study, we fabricated microneedles from a biocompatible polymer, namely, poly (ethylene glycol) diacrylate. A simple lithographical approach was developed for microneedle array fabrication. Several factors including polymerization time, ultraviolet light intensity and distance from light source were studied for their effects on microneedle formation. The microneedle length and tip diameter can be controlled by varying these factors. The microneedles were shown to be able to penetrate cadaver pig skin. Model drug rhodamine B was encapsulated in the range of 50 μg to 450 μg per microneedle array. The fabricated microneedles containing rhodamine B increased the permeability by four times than the control. Altogether, we demonstrated that the microneedle arrays can be fabricated through a simple single-step process and needles were mechanically strong to penetrate skin, increasing the permeability of encapsulated drug through skin. © 2013 Informa Healthcare USA, Inc.
Source Title: Drug Development and Industrial Pharmacy
ISSN: 03639045
DOI: 10.3109/03639045.2012.679361
Appears in Collections:Staff Publications

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