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Title: A novel time-controlled release system based on drug-resin complexes and elementary osmotic pump
Authors: Wang, C.
Chen, F.
Heng, P.W.S. 
Li, J.-Z.
Li, X.
Ye, G.-H.
Nie, S.-F.
Pan, W.-S.
Keywords: Drug release mechanism
Drug-resin complexes
Osmotic pump tablet
Propranolol hydrochloride
Time-controlled delivery
Issue Date: Apr-2008
Citation: Wang, C., Chen, F., Heng, P.W.S., Li, J.-Z., Li, X., Ye, G.-H., Nie, S.-F., Pan, W.-S. (2008-04). A novel time-controlled release system based on drug-resin complexes and elementary osmotic pump. Chemical and Pharmaceutical Bulletin 56 (4) : 457-463. ScholarBank@NUS Repository.
Abstract: A novel time-controlled system based on elementary osmotic pump tablet containing a drug-resin complexes (DRCs) core is presented. In the traditional osmotic pump tablets (OPTs), the lag time was always minimized. On the contrary, in the DRCs osmotic pump tablet (DRCOPT), the lag time was increased to achieve time-controlled delivery. The system led to a zero-order drug release after an initial lag time. Polyethylene oxide (PEO) N80 was used as suspension agent and NaCl was applied as ion-exchange, osmotic pressure (electrolyte supplementary) agent, respectively. To examine the mechanism of this system, drug release behaviors were investigated under conditions of various osmotic pressures. A new method of combination of conductivity and HPLC was applied to determine the different fractions of NaCl in producing osmotic pressure, ion-exchange and electrolyte supplement. The pharmacokinetic studies conducted in beagle dogs showed that a steadier and controlled drug release behavior was obtained compared with the traditional formulations. On the basis of prescription of the DRCOPT, a good in-vitro-in-vivo correlation (IVIVC, R2=.9541) was achieved. In addition, a lag time of 4 h was observed in in vivo experiment, which indicated that the DRCOPT can be used in therapeutic regimens with the characteristics of chronotherapy. © 2008 Pharmaceutical Society of Japan.
Source Title: Chemical and Pharmaceutical Bulletin
ISSN: 00092363
DOI: 10.1248/cpb.56.457
Appears in Collections:Staff Publications

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