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https://doi.org/10.1016/j.tetlet.2009.07.113
Title: | A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines | Authors: | Dolzhenko, A.V. Pastorin, G. Dolzhenko, A.V. Chui, W.K. |
Issue Date: | 7-Oct-2009 | Citation: | Dolzhenko, A.V., Pastorin, G., Dolzhenko, A.V., Chui, W.K. (2009-10-07). A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines. Tetrahedron Letters 50 (40) : 5617-5621. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2009.07.113 | Abstract: | A practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates in the preparation of adenosine receptor antagonists, is developed. The method allows introduction of a variety of aryl substituents at position 2 of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine system via cyclocondensation of 5-amino-4-iminopyrazolo[3,4-d]pyrimidine with benzaldehydes accompanied with oxidation by iodobenzene diacetate. Some unexpected reactions are observed and the structures of the products are confirmed using NMR spectroscopy and X-ray crystallography. © 2009 Elsevier Ltd. All rights reserved. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/105575 | ISSN: | 00404039 | DOI: | 10.1016/j.tetlet.2009.07.113 |
Appears in Collections: | Staff Publications |
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