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|Title:||A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines||Authors:||Dolzhenko, A.V.
|Issue Date:||7-Oct-2009||Citation:||Dolzhenko, A.V., Pastorin, G., Dolzhenko, A.V., Chui, W.K. (2009-10-07). A new synthesis of 2,8-disubstituted pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines. Tetrahedron Letters 50 (40) : 5617-5621. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2009.07.113||Abstract:||A practical synthesis of pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidines, which are key intermediates in the preparation of adenosine receptor antagonists, is developed. The method allows introduction of a variety of aryl substituents at position 2 of the pyrazolo[4,3-e][1,2,4]triazolo[1,5-c]pyrimidine system via cyclocondensation of 5-amino-4-iminopyrazolo[3,4-d]pyrimidine with benzaldehydes accompanied with oxidation by iodobenzene diacetate. Some unexpected reactions are observed and the structures of the products are confirmed using NMR spectroscopy and X-ray crystallography. © 2009 Elsevier Ltd. All rights reserved.||Source Title:||Tetrahedron Letters||URI:||http://scholarbank.nus.edu.sg/handle/10635/105575||ISSN:||00404039||DOI:||10.1016/j.tetlet.2009.07.113|
|Appears in Collections:||Staff Publications|
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