Please use this identifier to cite or link to this item: https://doi.org/10.1007/s13346-011-0044-0
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dc.titleA drug-laden elastomer for surgical treatment of anal fistula
dc.contributor.authorLi, H.
dc.contributor.authorJiang, B.
dc.contributor.authorYan, J.
dc.contributor.authorYang, Z.
dc.contributor.authorChen, Y.
dc.contributor.authorZhang, W.
dc.contributor.authorChoy, A.C.
dc.contributor.authorLee, C.-Y.M.
dc.contributor.authorKang, L.
dc.date.accessioned2014-10-29T01:47:19Z
dc.date.available2014-10-29T01:47:19Z
dc.date.issued2011-12
dc.identifier.citationLi, H., Jiang, B., Yan, J., Yang, Z., Chen, Y., Zhang, W., Choy, A.C., Lee, C.-Y.M., Kang, L. (2011-12). A drug-laden elastomer for surgical treatment of anal fistula. Drug Delivery and Translational Research 1 (6) : 439-447. ScholarBank@NUS Repository. https://doi.org/10.1007/s13346-011-0044-0
dc.identifier.issn2190393X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105561
dc.description.abstractAnal fistula is a common surgical problem with high incidence and causes suffering to patients. The management of high and complex anal fistula is challenging. The purpose of this work is to develop drug-laden elastomer not only to act as seton in the surgical management of anal fistula but also provide painkilling effect during the treatment. Elastic silicone bands were fabricated with different concentrations of lidocaine, with different in vitro drug release profiles. Muscle cutting experiment showed that the drug-laden elastic silicone bands were as effective as the surgical rubber bands in cutting function. Preliminary clinical trial indicated that the drug-laden silicone bands can be used as setons with analgesic effect in the treatment of anal fistula. The findings showed that the drug-laden elastic silicone bands are potentially useful as seton for surgical treatment of anal fistula. © 2011 Controlled Release Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1007/s13346-011-0044-0
dc.sourceScopus
dc.subjectAnal fistula
dc.subjectElasticity
dc.subjectLocal drug delivery
dc.subjectSeton
dc.subjectSilicone elastomer
dc.typeArticle
dc.contributor.departmentPHARMACY
dc.description.doi10.1007/s13346-011-0044-0
dc.description.sourcetitleDrug Delivery and Translational Research
dc.description.volume1
dc.description.issue6
dc.description.page439-447
dc.identifier.isiut000209423600005
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