Please use this identifier to cite or link to this item:
https://doi.org/10.1016/j.tetlet.2008.10.003
| Title: | A convenient method for the synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines | Authors: | Dolzhenko, A.V. Pastorin, G. Dolzhenko, A.V. Chui, W.K. |
Issue Date: | 8-Dec-2008 | Citation: | Dolzhenko, A.V., Pastorin, G., Dolzhenko, A.V., Chui, W.K. (2008-12-08). A convenient method for the synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines. Tetrahedron Letters 49 (50) : 7180-7183. ScholarBank@NUS Repository. https://doi.org/10.1016/j.tetlet.2008.10.003 | Abstract: | A new practical synthesis of 7-amino-substituted 1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amines is developed. The triazine ring closure of 5-guanidino-3-phenyl-1,2,4-triazole with trichloroacetonitrile proceeds chemo- and regioselectively depending on the nature of the solvent. Conducting the reaction in toluene provided 7-trichloromethyl-1,2,4-triazolo[1,5-a][1,3,5]triazin-5-amine as the product, which can be further aminated efficiently with replacement of the trichloromethyl group. © 2008 Elsevier Ltd. All rights reserved. | Source Title: | Tetrahedron Letters | URI: | http://scholarbank.nus.edu.sg/handle/10635/105557 | ISSN: | 00404039 | DOI: | 10.1016/j.tetlet.2008.10.003 |
| Appears in Collections: | Staff Publications |
Show full item record
Files in This Item:
There are no files associated with this item.
SCOPUSTM
Citations
33
checked on Jun 28, 2022
WEB OF SCIENCETM
Citations
31
checked on Oct 1, 2021
Page view(s)
155
checked on Jun 23, 2022
Google ScholarTM
Check
Altmetric
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.