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|Title:||Upper bounds and importance sampling of p-values for DNA and protein sequence alignments||Authors:||Chan, H.P.||Keywords:||Exponential tilting
|Issue Date:||Apr-2003||Citation:||Chan, H.P. (2003-04). Upper bounds and importance sampling of p-values for DNA and protein sequence alignments. Bernoulli 9 (2) : 183-199. ScholarBank@NUS Repository. https://doi.org/10.3150/bj/1068128974||Abstract:||We show in general how the substitution matrix and gap penalty function for local sequence alignments can be chosen such that the score statistic grows at a logarithmic rate when the two sequences are unrelated. The method used is the construction of a mixture distribution in which sequences with large scores are generated with uniformly higher likelihood. This distribution is also used for the importance sampling of the p-value of the score. An upper bound of this p-value is computed and compared against the simulated value. © 2003 ISI/BS.||Source Title:||Bernoulli||URI:||http://scholarbank.nus.edu.sg/handle/10635/105453||ISSN:||13507265||DOI:||10.3150/bj/1068128974|
|Appears in Collections:||Staff Publications|
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