Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1464-5491.2006.01836.x
Title: Smoking enhances absorption of insulin but reduces glucodynamic effects in individuals using the Lilly-Dura inhaled insulin system
Authors: Wise, S.
Chien, J.
Yeo, K. 
Richardson, C.
Keywords: Glucodynamic
Inhaled insulin
Insulin resistance
Pharmacokinetic
Smoking
Issue Date: May-2006
Citation: Wise, S., Chien, J., Yeo, K., Richardson, C. (2006-05). Smoking enhances absorption of insulin but reduces glucodynamic effects in individuals using the Lilly-Dura inhaled insulin system. Diabetic Medicine 23 (5) : 510-515. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1464-5491.2006.01836.x
Abstract: Aim: To quantify the pharmacokinetic (PK) and glucodynamic (GD) impact of smoking on inhaled and subcutaneous (SC) insulin administration in healthy subjects. Methods: This study employed the euglycemic clamp procedure in a four-period, four-way randomized crossover design. Eight smoking and eight non-smoking healthy males were given SC insulin on two occasions and human insulin inhalation powder (HIIP) on two other occasions. Results: Smokers exhibited greater insulin exposure (AUC0-t′) than non-smokers, following both routes of insulin administration (HIIP, P = 0.003, 58% increase; SC, P = 0.006, 24% increase). The maximum insulin concentration (Cmax) following HIIP was greater in smokers by 172% (P = 0.001) compared with non-smokers. The glucodynamic effects were greater in smokers following HIIP, consistent with the insulin concentration difference observed. However, maximum glucose response (Rmax) following SC was decreased by 36% (P = 0.001) and obtained later [time of maximum glucose response (TRmax); P < 0.001] in smokers than in non-smokers. Smokers appeared less sensitive to insulin [total glucose infused during the clamp procedure normalised by total insulin exposure (Gtot)/AUC0-t′] than non-smokers following both SC (P = 0.001) and inhaled (P = 0.011) routes of administration. Conclusion: Smokers had substantially increased peak HIIP insulin concentration, but the glucodynamic effect was partially offset, most likely because of increased insulin resistance. © 2006 Diabetes UK.
Source Title: Diabetic Medicine
URI: http://scholarbank.nus.edu.sg/handle/10635/105373
ISSN: 07423071
DOI: 10.1111/j.1464-5491.2006.01836.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

18
checked on Jan 13, 2022

WEB OF SCIENCETM
Citations

16
checked on Jan 13, 2022

Page view(s)

111
checked on Jan 20, 2022

Google ScholarTM

Check

Altmetric


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.