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Title: Smoking enhances absorption of insulin but reduces glucodynamic effects in individuals using the Lilly-Dura inhaled insulin system
Authors: Wise, S.
Chien, J.
Yeo, K. 
Richardson, C.
Keywords: Glucodynamic
Inhaled insulin
Insulin resistance
Issue Date: May-2006
Citation: Wise, S., Chien, J., Yeo, K., Richardson, C. (2006-05). Smoking enhances absorption of insulin but reduces glucodynamic effects in individuals using the Lilly-Dura inhaled insulin system. Diabetic Medicine 23 (5) : 510-515. ScholarBank@NUS Repository.
Abstract: Aim: To quantify the pharmacokinetic (PK) and glucodynamic (GD) impact of smoking on inhaled and subcutaneous (SC) insulin administration in healthy subjects. Methods: This study employed the euglycemic clamp procedure in a four-period, four-way randomized crossover design. Eight smoking and eight non-smoking healthy males were given SC insulin on two occasions and human insulin inhalation powder (HIIP) on two other occasions. Results: Smokers exhibited greater insulin exposure (AUC0-t′) than non-smokers, following both routes of insulin administration (HIIP, P = 0.003, 58% increase; SC, P = 0.006, 24% increase). The maximum insulin concentration (Cmax) following HIIP was greater in smokers by 172% (P = 0.001) compared with non-smokers. The glucodynamic effects were greater in smokers following HIIP, consistent with the insulin concentration difference observed. However, maximum glucose response (Rmax) following SC was decreased by 36% (P = 0.001) and obtained later [time of maximum glucose response (TRmax); P < 0.001] in smokers than in non-smokers. Smokers appeared less sensitive to insulin [total glucose infused during the clamp procedure normalised by total insulin exposure (Gtot)/AUC0-t′] than non-smokers following both SC (P = 0.001) and inhaled (P = 0.011) routes of administration. Conclusion: Smokers had substantially increased peak HIIP insulin concentration, but the glucodynamic effect was partially offset, most likely because of increased insulin resistance. © 2006 Diabetes UK.
Source Title: Diabetic Medicine
ISSN: 07423071
DOI: 10.1111/j.1464-5491.2006.01836.x
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