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Title: Serum gamma-glutamyl transferase level and diabetes mellitus among US adults
Authors: Sabanayagam, C.
Shankar, A.
Li, J. 
Pollard, C.
Ducatman, A.
Keywords: Diabetes mellitus
Gamma-glutamyl transferase
Issue Date: Jul-2009
Citation: Sabanayagam, C., Shankar, A., Li, J., Pollard, C., Ducatman, A. (2009-07). Serum gamma-glutamyl transferase level and diabetes mellitus among US adults. European Journal of Epidemiology 24 (7) : 369-373. ScholarBank@NUS Repository.
Abstract: Serum gamma-glutamyl transferase (GGT), a marker of oxidative stress, has been shown to be associated with diabetes mellitus in some population-based studies, but not all. Also, it is not clear if there is a continuous dose-response relationship in this association, or if this association is evident only beyond a particular threshold level of GGT. We examined the association between serum GGT and diabetes mellitus in a representative sample of US adults aged >20 years, in a cross-sectional study involving 7,976 National Health and Nutrition Examination Survey 1999-2002 participants. Diabetes mellitus was defined as a fasting glucose > 126mg/dl, nonfasting glucose >200 mg/dl, or use of oral hypoglycemic medication or insulin (n = 805). Higher serum GGT levels were positively associated with diabetes mellitus, independent of, alcohol consumption, body mass index, hypertension and other confounders. Multivariable odds ratio (95% confidence interval) comparing quartile 4 of GGT (>33 U/L) to quartile 1 (
Source Title: European Journal of Epidemiology
ISSN: 03932990
DOI: 10.1007/s10654-009-9346-7
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