Please use this identifier to cite or link to this item:
DC FieldValue
dc.titleReduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma
dc.contributor.authorVon Jagwitz, M.
dc.contributor.authorPessler, F.
dc.contributor.authorAkmatov, M.
dc.contributor.authorLi, J.
dc.contributor.authorRange, U.
dc.contributor.authorVogelberg, C.
dc.identifier.citationVon Jagwitz, M., Pessler, F., Akmatov, M., Li, J., Range, U., Vogelberg, C. (2011-07). Reduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma. Journal of Allergy and Clinical Immunology 128 (1) : 50-55. ScholarBank@NUS Repository.
dc.description.abstractBackground: Early noninvasive detection of increased risk of asthma with exhaled breath condensate (EBC) pH measurement has not been applied to preschool children. Objective: We sought to evaluate the ability of EBC pH measurement to identify young asymptomatic children at risk of asthma using the combination of recurrent wheezing and atopic sensitization as a proxy for a high risk of asthma. Methods: pH values were measured in deaerated EBC from 191 children (median age, 4.4 years [interquartile range, 2.2 years]). Children were divided into one of 5 groups: asymptomatic children with recurrent wheezy bronchitis with (group 1, n = 34) or without (group 2, n = 64) allergic sensitization, acute wheezy bronchitis (group 3, n = 18), allergic rhinoconjunctivitis without recurrent wheezy bronchitis (group 4, n = 15), and healthy control subjects (group 5, n = 60). The Asthma Predictive Index score was calculated for groups 1 and 2. Statistical significance was evaluated with the appropriate nonparametric tests, and the discriminatory accuracy was evaluated with receiver operating characteristic analysis. Results: Deaerated EBC pH values were significantly lower in groups 1 and 3 than in groups 2, 4, and 5 (median, 7.49 [interquartile range, 0.94] and 7.44 [interquartile range, 0.70] vs 7.93 [interquartile range, 0.23], 8.02 [interquartile range, 0.17], and 7.96 [interquartile range, 0.25], respectively; P
dc.subjectallergic sensitization
dc.subjectAsthma Predictive Index
dc.subjectearly childhood asthma
dc.subjectexhaled breath condensate pH
dc.subjectrecurrent wheezy bronchitis
dc.contributor.departmentSTATISTICS & APPLIED PROBABILITY
dc.description.sourcetitleJournal of Allergy and Clinical Immunology
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.