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Title: Reduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma
Authors: Von Jagwitz, M.
Pessler, F.
Akmatov, M.
Li, J. 
Range, U.
Vogelberg, C.
Keywords: allergic sensitization
Asthma Predictive Index
early childhood asthma
exhaled breath condensate pH
recurrent wheezy bronchitis
Issue Date: Jul-2011
Citation: Von Jagwitz, M., Pessler, F., Akmatov, M., Li, J., Range, U., Vogelberg, C. (2011-07). Reduced breath condensate pH in asymptomatic children with prior wheezing as a risk factor for asthma. Journal of Allergy and Clinical Immunology 128 (1) : 50-55. ScholarBank@NUS Repository.
Abstract: Background: Early noninvasive detection of increased risk of asthma with exhaled breath condensate (EBC) pH measurement has not been applied to preschool children. Objective: We sought to evaluate the ability of EBC pH measurement to identify young asymptomatic children at risk of asthma using the combination of recurrent wheezing and atopic sensitization as a proxy for a high risk of asthma. Methods: pH values were measured in deaerated EBC from 191 children (median age, 4.4 years [interquartile range, 2.2 years]). Children were divided into one of 5 groups: asymptomatic children with recurrent wheezy bronchitis with (group 1, n = 34) or without (group 2, n = 64) allergic sensitization, acute wheezy bronchitis (group 3, n = 18), allergic rhinoconjunctivitis without recurrent wheezy bronchitis (group 4, n = 15), and healthy control subjects (group 5, n = 60). The Asthma Predictive Index score was calculated for groups 1 and 2. Statistical significance was evaluated with the appropriate nonparametric tests, and the discriminatory accuracy was evaluated with receiver operating characteristic analysis. Results: Deaerated EBC pH values were significantly lower in groups 1 and 3 than in groups 2, 4, and 5 (median, 7.49 [interquartile range, 0.94] and 7.44 [interquartile range, 0.70] vs 7.93 [interquartile range, 0.23], 8.02 [interquartile range, 0.17], and 7.96 [interquartile range, 0.25], respectively; P
Source Title: Journal of Allergy and Clinical Immunology
ISSN: 00916749
DOI: 10.1016/j.jaci.2011.03.005
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