Please use this identifier to cite or link to this item:
Title: Quantitative determination of the diagnostic accuracy of the synovitis score and its components
Authors: Slansky, E.
Li, J. 
Häupl, T.
Morawietz, L.
Krenn, V.
Pessler, F.
Keywords: osteoarthritis
receiver operating characteristic analysis
rheumatoid arthritis
Issue Date: Sep-2010
Citation: Slansky, E., Li, J., Häupl, T., Morawietz, L., Krenn, V., Pessler, F. (2010-09). Quantitative determination of the diagnostic accuracy of the synovitis score and its components. Histopathology 57 (3) : 436-443. ScholarBank@NUS Repository.
Abstract: Aims: To assess the diagnostic accuracy of a three-component synovitis score and to determine the relative contribution of each of its components to its overall discriminatory power. Methods and results: The synovitis score was determined in 666 synovial specimens: normal synovium, n = 33; post-traumatic arthropathy (PtA), n = 29; osteoarthritis (OA), n = 221; psoriatic arthritis (PsA), n = 42; and rheumatoid arthritis (RA), n = 341. The discriminatory abilities of the score and its components were quantified with binary and multicategory receiver operating characteristic (ROC) analysis. The score differentiated all arthropathies accurately from normal tissue (area under the ROC curve, AUC: 0.87-0.98) and RA from OA or PtA (AUC: 0.85 for both), but could not distinguish well within pairs of inflammatory or degenerative arthropathies. AUCs of the intimal hyperplasia and stromal cellularity components correlated with the AUCs of the complete score markedly more strongly (r = 0.94 and 0.91, respectively) than the inflammatory infiltration component (r = 0.60). Multicategory ROC analysis ranked the score several-fold higher than any of its components, and the components in the order stromal cellularity>intimal hyperplasia>infiltration. Conclusion: Combining three distinct histological parameters into a three-component score produces greatly increased overall diagnostic power. The discriminatory ability of the score stems more from measuring proliferative than infiltrative aspects of synovitis. © 2010 Blackwell Publishing Limited.
Source Title: Histopathology
ISSN: 03090167
DOI: 10.1111/j.1365-2559.2010.03641.x
Appears in Collections:Staff Publications

Show full item record
Files in This Item:
There are no files associated with this item.


checked on Oct 31, 2020


checked on Oct 23, 2020

Page view(s)

checked on Oct 10, 2020

Google ScholarTM



Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.