Please use this identifier to cite or link to this item: https://doi.org/10.1038/sj.ijo.0802307
Title: Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects
Authors: Liew, C.-F.
Seah, E.-S.
Yeo, K.-P. 
Lee, K.-O.
Wise, S.D.
Keywords: Ethnicity
Indian
Insulin clearance
Insulin sensitivity
Leptin
Issue Date: 1-Jul-2003
Citation: Liew, C.-F., Seah, E.-S., Yeo, K.-P., Lee, K.-O., Wise, S.D. (2003-07-01). Lean, nondiabetic Asian Indians have decreased insulin sensitivity and insulin clearance, and raised leptin compared to Caucasians and Chinese subjects. International Journal of Obesity 27 (7) : 784-789. ScholarBank@NUS Repository. https://doi.org/10.1038/sj.ijo.0802307
Abstract: OBJECTIVE: To study and compare the insulin sensitivity of healthy, nondiabetic Asian Indians with that of two other ethnic groups (Caucasian and Chinese) living in Singapore. DESIGN: Study of insulin sensitivity using euglycaemic hyperinsulinaemic glucose clamp. SUBJECTS: A total of 10 healthy, lean, young male subjects of each ethnic group, matched for age, body mass index (BMI) and physical activity. They all had normal glucose tolerance and had no family history of diabetes. MEASUREMENTS: Anthropometric parameters (BMI, waist-hip ratio (WHR) and percentage body fat (PBF)), fasting lipid profile and leptin concentration, insulin sensitivity index, and insulin clearance. RESULTS: Healthy lean (BMI 22.1 ± 1.5 kg/m2 (mean ± s.d.)) Indians had significantly higher fasting serum leptin (5.1 ± 2.5 vs Chinese 1.0±0.9 vs Caucasian 2.3±1.2 ng/ml; P
Source Title: International Journal of Obesity
URI: http://scholarbank.nus.edu.sg/handle/10635/105191
ISSN: 03070565
DOI: 10.1038/sj.ijo.0802307
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