Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/105183
DC FieldValue
dc.titleInsulin-like growth factor binding protein-1 is independently affected by ethnicity, insulin sensitivity, and leptin in healthy, glucose-tolerant young men
dc.contributor.authorLiew, C.F.
dc.contributor.authorWise, S.D.
dc.contributor.authorYeo, K.P.
dc.contributor.authorLee, K.O.
dc.date.accessioned2014-10-28T05:12:44Z
dc.date.available2014-10-28T05:12:44Z
dc.date.issued2005-03
dc.identifier.citationLiew, C.F., Wise, S.D., Yeo, K.P., Lee, K.O. (2005-03). Insulin-like growth factor binding protein-1 is independently affected by ethnicity, insulin sensitivity, and leptin in healthy, glucose-tolerant young men. Journal of Clinical Endocrinology and Metabolism 90 (3) : 1483-1488. ScholarBank@NUS Repository.
dc.identifier.issn0021972X
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/105183
dc.description.abstractWe examined the relationships among IGF binding protein (IGFBP)-1, insulin sensitivity, and leptin in different ethnic groups (Asian Indians, Chinese, and Caucasians) using the euglycemic hyperinsulinemic clamp. Ten healthy, young and nondiabetic subjects of each ethnic group, matched for body mass index, age, and physical activity were studied. A euglycemic clamp was performed on all subjects. IGFBP-1, insulin, and leptin were measured after fasting and during the clamp. Fasting IGFBP-1 concentration was highest in Chinese (P = 0.027). Asian Indians had the lowest insulin sensitivity index (P = 0.006). The ratio of insulin to IGFBP-1 at fasting and throughout the euglycemic clamp was higher in Asian Indians. Fasting IGFBP-1 had a strong negative correlation with fasting leptin levels (r = -0.715, P = 0.001). Multiple linear regression demonstrated that fasting insulin, leptin, ethnicity, and insulin sensitivity were significant predictors for fasting IGFBP-1. IGFBP-1 is independently determined by ethnicity, insulin sensitivity, and leptin in glucose-tolerant men. The presence of relative insulin resistance and low fasting IGFBP-1 levels in Asian Indians may contribute to their higher risk of developing diabetes and cardiovascular disease. Copyright © 2005 by The Endocrine Society.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1210/jc.2004-1501
dc.sourceScopus
dc.typeArticle
dc.contributor.departmentSTATISTICS & APPLIED PROBABILITY
dc.description.sourcetitleJournal of Clinical Endocrinology and Metabolism
dc.description.volume90
dc.description.issue3
dc.description.page1483-1488
dc.description.codenJCEMA
dc.identifier.isiut000227523600033
Appears in Collections:Staff Publications

Show simple item record
Files in This Item:
There are no files associated with this item.

SCOPUSTM   
Citations

23
checked on Mar 8, 2018

WEB OF SCIENCETM
Citations

26
checked on Oct 5, 2021

Page view(s)

79
checked on Jun 23, 2022

Google ScholarTM

Check


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.