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Title: Information Recovery in a Study with Surrogate Endpoints
Authors: Chen, S.X. 
Leung, D.H.Y.
Qin, J.
Keywords: Auxiliary outcome
Bartlett correction
Confidence regions
Empirical likelihood
Estimating equations
Surrogate endpoint
Issue Date: Dec-2003
Citation: Chen, S.X., Leung, D.H.Y., Qin, J. (2003-12). Information Recovery in a Study with Surrogate Endpoints. Journal of the American Statistical Association 98 (464) : 1052-1062. ScholarBank@NUS Repository.
Abstract: Recently, there has been a lot of interest in statistical methods for analyzing data with surrogate endpoints. In this article, we consider parameter estimation from a model that relates a variable Y to a set of covariates, X, in the presence of a surrogate, 5. We assume that the data are made up of two random samples from the population, a validation set where (Y, X, S) are observed on every subject and a nonvalidation set where only (X, S) are measured. We show how information from the nonvalidation set can be incorporated to improve upon estimation of a parameter β using the validation data only. The method we suggest does not require knowledge on the joint distribution between (Y, S), given X. It is based on a two-sample empirical likelihood that simultaneously combines the estimating equations from the validation set and the nonvalidation set. The proposed nonparametric likelihood formulation brings a few attractive features to the inference in β. First, the maximum empirical likelihood estimate is more efficient than that using only the validation sample. Second, confidence regions can be readily constructed without the need to estimate the variance-covariance matrix. Finally, the coverage of the confidence regions can be further improved by an empirical Bartlett correction based on the bootstrap. We show that the method gives favorable results in simulation studies.
Source Title: Journal of the American Statistical Association
ISSN: 01621459
DOI: 10.1198/016214503000000972
Appears in Collections:Staff Publications

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