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|dc.title||Effect of duloxetine on tolterodine pharmacokinetics in healthy volunteers|
|dc.identifier.citation||Hua, T.C., Pan, A., Chan, C., Poo, Y.K., Skinner, M.H., Knadler, M.P., Gonzales, C.R., Wise, S.D. (2004-05). Effect of duloxetine on tolterodine pharmacokinetics in healthy volunteers. British Journal of Clinical Pharmacology 57 (5) : 652-656. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1365-2125.2004.02068.x|
|dc.description.abstract||Aim: To investigate the effect of duloxetine on the pharmacokinetics and tolerability of tolterodine and its active 5-hydroxymethyl metabolite (5-HM). Methods: Sixteen healthy subjects received two 5-day treatment regimens in a randomized, double-blinded, crossover fashion: tolterodine (2 mg, BID) + duloxetine (40 mg, BID), tolterodine (2 mg, BID) + duloxetine placebo (BID). Plasma concentrations of tolterodine and 5-HM were measured on day 5. Adverse events, clinical safety laboratory data and vital signs were assessed during the study. Results: Duloxetine increased the AUCτ,ss of tolterodine by 71% [geometric mean, 95% confidence interval (CI) 31, 123], and its C max,ss by 64% (CI 30, 106), and prolonged its t1/2 by 14% (CI 1, 28). Duloxetine did not affect the plasma concentrations or t 1/2 of 5-HM. Laboratory data and vital signs did not reveal any clinically significant changes or abnormalities. Conclusions: Duloxetine exhibited minor inhibitory effects on the pharmacokinetics of tolterodine but not 5-HM. Coadministration of these drugs was well tolerated and demonstrated no significant safety findings in the studied population. These findings suggest that there should not be a need for routine adjustment of tolterodine dosage in the presence of duloxetine.|
|dc.contributor.department||STATISTICS & APPLIED PROBABILITY|
|dc.description.sourcetitle||British Journal of Clinical Pharmacology|
|Appears in Collections:||Staff Publications|
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