Please use this identifier to cite or link to this item: https://doi.org/10.1111/j.1365-2125.2006.02770.x
Title: Duloxetine pharmacokinetics are similar in Japanese and Caucasian subjects
Authors: Chan, C.
Yeo, K.P. 
Pan, A.X.
Lim, M.
Knadler, M.P.
Small, D.S.
Keywords: CYP1A2
CYP2D6
Duloxetine
Pharmacokinetics
Race
Issue Date: Mar-2007
Citation: Chan, C., Yeo, K.P., Pan, A.X., Lim, M., Knadler, M.P., Small, D.S. (2007-03). Duloxetine pharmacokinetics are similar in Japanese and Caucasian subjects. British Journal of Clinical Pharmacology 63 (3) : 310-314. ScholarBank@NUS Repository. https://doi.org/10.1111/j.1365-2125.2006.02770.x
Abstract: Aims: To compare single- and multiple-dose duloxetine pharmacokinetics between healthy Japanese and Caucasians. Methods: Twenty-four subjects of each race were given single oral doses of duloxetine (20, 40 and 60 mg) in a randomized, double-blind study. Another 20 subjects of each race received 20, 40 mg or placebo (2 : 2 : 1) twice-daily for 5 days. Results: Following single doses, the mean duloxetine Cmax and AUC were approximately 20% greater in Japanese. This difference could be explained by the 15% lower average body weight in Japanese. Similar results were observed following multiple dosing. Conclusion: Duloxetine pharmacokinetics are not meaningfully different between Japanese and Caucasians. © 2006 Eli Lilly and Company.
Source Title: British Journal of Clinical Pharmacology
URI: http://scholarbank.nus.edu.sg/handle/10635/105097
ISSN: 03065251
DOI: 10.1111/j.1365-2125.2006.02770.x
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