Models and Methods in Comparative Genomics

Abstract

Comparative genomics is the analysis and comparison of genomes from different species. In recent years, in conjunction with the growing number of available sequenced genomes, this field has undergone a rapid expansion. In the current survey, we review models and methods associated with four important research topics in this area that have interesting computational and statistical components: genome rearrangements, gene duplication, phylogenetic networks and positional gene clustering. The survey aims at balancing between presenting classical results and promising new developments. © 2006 Elsevier Inc. All rights reserved.