Please use this identifier to cite or link to this item: https://doi.org/10.1517/17425255.2011.562197
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dc.titleZebrafish for drug toxicity screening: Bridging the in vitro cell-based models and in vivo mammalian models
dc.contributor.authorSukardi, H.
dc.contributor.authorChng, H.T.
dc.contributor.authorChan, E.C.Y.
dc.contributor.authorGong, Z.
dc.contributor.authorLam, S.H.
dc.date.accessioned2014-10-27T08:49:50Z
dc.date.available2014-10-27T08:49:50Z
dc.date.issued2011-05
dc.identifier.citationSukardi, H., Chng, H.T., Chan, E.C.Y., Gong, Z., Lam, S.H. (2011-05). Zebrafish for drug toxicity screening: Bridging the in vitro cell-based models and in vivo mammalian models. Expert Opinion on Drug Metabolism and Toxicology 7 (5) : 579-589. ScholarBank@NUS Repository. https://doi.org/10.1517/17425255.2011.562197
dc.identifier.issn17425255
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/102588
dc.description.abstractIntroduction: Over the past decade, zebrafish have been tasked to play important roles from modeling human diseases to finding cures for them. Inadvertently, these fish now find themselves swimming along the drug development pipeline. A number of studies have been conducted to see if these small fish are up to the task of drug toxicity testing, an important rite of passage along the pharmaceutical pipeline. Areas covered: This review covers the recent publications (2008 - 2010) on the state-of-the-art applications that couple advanced technologies with the unique advantages of zebrafish for drug toxicity screening. The paper looks at the several automated high-throughput platforms that have been developed for zebrafish teratogenicity, cardiotoxicity and neuro-sensory organ toxicity assays over the past 3 years as well as the important studies related to metabolism and biotransformation of selected drugs that have been initiated. This paper also reviews their mechanistic and predictive omics applications. Expert opinion: While there have been a number of developments over the past 3 years and indeed over the last 10 years, challenges and limitations still exist, which, unless overcome, will prevent zebrafish from truly reaching their full potential as a drug toxicological model. That being said, recent developments have suggested that zebrafish could play a role in bridging the gap between in vitro cell-based models and in vivo mammalian models. © 2011 Informa UK, Ltd.
dc.description.urihttp://libproxy1.nus.edu.sg/login?url=http://dx.doi.org/10.1517/17425255.2011.562197
dc.sourceScopus
dc.subjectcardiotoxicity
dc.subjectdrug toxicity screening
dc.subjecthigh-throughput phenotype-based screening
dc.subjectneuro-sensory organ toxicity
dc.subjectomics applications
dc.subjectsafety pharmacology
dc.subjectteratogenicity
dc.subjectzebrafish
dc.typeReview
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.contributor.departmentPHARMACY
dc.description.doi10.1517/17425255.2011.562197
dc.description.sourcetitleExpert Opinion on Drug Metabolism and Toxicology
dc.description.volume7
dc.description.issue5
dc.description.page579-589
dc.identifier.isiut000289684800005
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