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Title: Structural determinants of protein folding
Authors: Kang, T.S. 
Kini, R.M. 
Keywords: Folding models
Folding propensity
Posttranslational modifications
Protein folding
Secondary structures
Structural determinants
Issue Date: Jul-2009
Citation: Kang, T.S., Kini, R.M. (2009-07). Structural determinants of protein folding. Cellular and Molecular Life Sciences 66 (14) : 2341-2361. ScholarBank@NUS Repository.
Abstract: The last several decades have seen an explosion of knowledge in the field of structural biology. With critical advances in spectroscopic techniques in examining structures of biomacromolecules, in maturation of molecular biology techniques, as well as vast improvements in computation prowess, protein structures are now being elucidated at an unprecedented rate. In spite of all the recent advances, the protein folding puzzle remains as one of the fundamental biochemical challenges. A facet to this empiric problem is the structural determinants of protein folding. What are the driving forces that pivot a polypeptide chain to a specific conformation amongst the vast conformation space? In this review, we shall discuss some of the structural determinants to protein folding that have been identified in the recent decades. © 2009 Birkhäuser Verlag, Basel/Switzerland.
Source Title: Cellular and Molecular Life Sciences
ISSN: 1420682X
DOI: 10.1007/s00018-009-0023-5
Appears in Collections:Staff Publications

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