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Title: Quorum sensing and quorum-quenching enzymes
Authors: Dong, Y.-H.
Zhang, L.-H. 
Keywords: AHL-acylase
Quorum quenching enzymes
Quorum sensing
Signal interference
Issue Date: Feb-2005
Citation: Dong, Y.-H.,Zhang, L.-H. (2005-02). Quorum sensing and quorum-quenching enzymes. Journal of Microbiology 43 : 101-109. ScholarBank@NUS Repository.
Abstract: To gain maximal benefit in a competitive environment, single-celled bacteria have adopted a community genetic regulatory mechanism, known as quorum sensing (QS). Many bacteria use QS signaling systems to synchronize target gene expression and coordinate biological activities among a local population. N-acylhomoserine lactones (AHLs) are one family of the well-characterized QS signals in Gram-negative bacteria, which regulate a range of important biological functions, including virulence and biofilm formation. Several groups of AHL-degradation enzymes have recently been identified in a range of living organisms, including bacteria and eukaryotes. Expression of these enzymes in AHL-dependent pathogens and transgenic plants efficiently quenches the microbial QS signaling and blocks pathogenic infections. Discovery of these novel quorum quenching enzymes has not only provided a promising means to control bacterial infections, but also presents new challenges to investigate their roles in host organisms and their potential impacts on ecosystems. Copyright © 2005, The Microbiological Society of Korea.
Source Title: Journal of Microbiology
ISSN: 12258873
Appears in Collections:Staff Publications

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