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Title: Quorum quenching and proactive host defense
Authors: Zhang, L.-H. 
Issue Date: 1-May-2003
Citation: Zhang, L.-H. (2003-05-01). Quorum quenching and proactive host defense. Trends in Plant Science 8 (5) : 238-244. ScholarBank@NUS Repository.
Abstract: Both plants and humans have inducible defense mechanisms. This passive defense strategy leaves the host unprotected for a period of time until resistance is activated. Moreover, many bacterial pathogens have evolved cell-cell communication (quorum-sensing) mechanisms to mount population-density-dependent attacks to overwhelm the host's defense responses. Several chemicals and enzymes have been investigated for years for their potential to target the key components of bacterial quorum-sensing systems. These quorum-quenching reagents, which block bacterial cell-cell communications, can disintegrate a bacterial population-density-dependent attack. It has now been shown that a quorum-quenching mechanism can be engineered in plants and might be used as a strategy in controlling bacterial pathogens and to build up a proactive defense barrier.
Source Title: Trends in Plant Science
ISSN: 13601385
DOI: 10.1016/S1360-1385(03)00063-3
Appears in Collections:Staff Publications

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