Please use this identifier to cite or link to this item: https://scholarbank.nus.edu.sg/handle/10635/102491
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dc.titleModeling liver cancer using zebrafish: A comparative oncogenomics approach
dc.contributor.authorSiew, H.L.
dc.contributor.authorGong, Z.
dc.date.accessioned2014-10-27T08:48:47Z
dc.date.available2014-10-27T08:48:47Z
dc.date.issued2006-03-16
dc.identifier.citationSiew, H.L.,Gong, Z. (2006-03-16). Modeling liver cancer using zebrafish: A comparative oncogenomics approach. Cell Cycle 5 (6) : 573-577. ScholarBank@NUS Repository.
dc.identifier.issn15384101
dc.identifier.urihttp://scholarbank.nus.edu.sg/handle/10635/102491
dc.description.abstractAlthough the zebrafish has many attributes of a promising cancer model, one outstanding question is how similar zebrafish and human tumors are at the molecular level. To date, supporting data from histology and 'gene-to-gene' comparisons with human data offer limited insights. Using comparative microarray analyses, we found striking molecular similarities between zebrafish and human liver neoplasia. Our data indicate that zebrafish liver tumors possess the general molecular hallmarks of human liver cancer and some of the molecular similarities extend to the progression of liver tumors. The molecular conservation between fish and human liver tumors underscored the strong association and fundamental importance of these genes in liver neoplasia as well as their clinical potentials as diagnostic markers and/or therapeutic targets. In addition, our comparative oncogenomic work provides a general framework for comparing and validating microarray data of zebrafish model with human cancer, thus adding confidence of using the zebrafish to model human cancers. ©2006 Landes Bioscience.
dc.sourceScopus
dc.subjectCancer model
dc.subjectComparative oncogenomics
dc.subjectDNA microarray
dc.subjectGene expression profiling
dc.subjectLiver tumor
dc.subjectZebrafish
dc.typeReview
dc.contributor.departmentBIOLOGICAL SCIENCES
dc.description.sourcetitleCell Cycle
dc.description.volume5
dc.description.issue6
dc.description.page573-577
dc.identifier.isiutNOT_IN_WOS
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