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Title: Modeling liver cancer using zebrafish: A comparative oncogenomics approach
Authors: Siew, H.L. 
Gong, Z. 
Keywords: Cancer model
Comparative oncogenomics
DNA microarray
Gene expression profiling
Liver tumor
Issue Date: 16-Mar-2006
Citation: Siew, H.L.,Gong, Z. (2006-03-16). Modeling liver cancer using zebrafish: A comparative oncogenomics approach. Cell Cycle 5 (6) : 573-577. ScholarBank@NUS Repository.
Abstract: Although the zebrafish has many attributes of a promising cancer model, one outstanding question is how similar zebrafish and human tumors are at the molecular level. To date, supporting data from histology and 'gene-to-gene' comparisons with human data offer limited insights. Using comparative microarray analyses, we found striking molecular similarities between zebrafish and human liver neoplasia. Our data indicate that zebrafish liver tumors possess the general molecular hallmarks of human liver cancer and some of the molecular similarities extend to the progression of liver tumors. The molecular conservation between fish and human liver tumors underscored the strong association and fundamental importance of these genes in liver neoplasia as well as their clinical potentials as diagnostic markers and/or therapeutic targets. In addition, our comparative oncogenomic work provides a general framework for comparing and validating microarray data of zebrafish model with human cancer, thus adding confidence of using the zebrafish to model human cancers. ©2006 Landes Bioscience.
Source Title: Cell Cycle
ISSN: 15384101
Appears in Collections:Staff Publications

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