Please use this identifier to cite or link to this item: https://doi.org/10.1016/j.mce.2009.05.012
Title: Hormonal signaling to follicle stimulating hormone β-subunit gene expression
Authors: Melamed, P. 
Keywords: Activin
FSH
GnRH
Gonadotrope
Pituitary
Steroids
Transcription
Issue Date: 27-Jan-2010
Citation: Melamed, P. (2010-01-27). Hormonal signaling to follicle stimulating hormone β-subunit gene expression. Molecular and Cellular Endocrinology 314 (2) : 204-212. ScholarBank@NUS Repository. https://doi.org/10.1016/j.mce.2009.05.012
Abstract: Expression of the hormone-specific β-subunit of follicle stimulating hormone (FSHβ) is regulated primarily by gonadotropin releasing hormone (GnRH) and activin, with additional feedback by various steroids. While the nature of this hormonal regulation appears conserved, the molecular mechanisms mediating these effects appear less so. This is apparent from the diverse cis-elements required for hormonal stimulation in different species, distinct transcription factors that seem to mediate the effects, as well as the lack of conservation of several reportedly functional cis-elements across species. Recent additional information on the molecular mechanisms through which these regulatory hormones exert their effects, supports the possibility of species-specific mechanisms of regulation, while some redundancy may exist in signaling by the activated transcription factors which allows preservation of the hormonal regulation in these different promoter contexts. © 2009 Elsevier Ireland Ltd. All rights reserved.
Source Title: Molecular and Cellular Endocrinology
URI: http://scholarbank.nus.edu.sg/handle/10635/102464
ISSN: 03037207
DOI: 10.1016/j.mce.2009.05.012
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